A Major Single Nucleotide Polymorphism of the PDLIM5 Gene Associated with Recurrent Major Depressive Disorder

Overview

Journal J Psychiatry Neurosci

Specialty Psychiatry

Date 2008 Jan 17

PMID 18197271

Citations 12

Authors

Zhongchun Liu

Wanhong Liu

Zheman Xiao

Gaohua Wang

Shijin Yin

Fan Zhu

Huiling Wang

Jin Cheng

Xiaoping Wang

Xiaohua He

Wenxin Li

Affiliations

Soon will be listed here.

Abstract

Objective: The PDLIM5 gene is known to interact specifically with the N-type calcium channel alpha-1B subunit and protein kinase C epsilon and is critical for rapid, efficient potentiation of the calcium channel activation by protein kinase C in neurons. Increasing amounts of data suggested that PDLIM5 might be involved in the pathophysiology of major depressive disorder (MDD). The aim of this study was to examine whether genetic variations in the human PDLIM5 gene might contribute to the liability to develop MDD.

Method: We undertook a gene-based association analysis of single nucleotide polymorphisms (SNPs). Three SNPs (rs10008257, rs2433320 and rs2452600) were identified in the PDLIM5 gene and genotyped in patients diagnosed with recurrent MDD and in matched control subjects.

Results: We observed significant allele (p = 0.007) and genotype (p = 0.007) association with rs2433320, and the G allele of rs2433320 was significantly overrepresented in control subjects in comparison with MDD patients.

Conclusion: These results support the hypothesis of a protective effect for the G allele of rs2433320 in the PDLIM5 gene in recurrent MDD.

Citing Articles

Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching.

Srivastava Y, Donta M, Mireles L, Paulucci-Holthauzen A, Shi L, Bedford M Int J Mol Sci. 2024; 25(15).

PMID: 39125895 PMC: 11312917. DOI: 10.3390/ijms25158326.

Expression of PDLIM5 Spliceosomes and Regulatory Functions on Myogenesis in Pigs.

Fu Y, Li S, Nie J, Yan D, Zhang B, Hao X Cells. 2024; 13(8.

PMID: 38667334 PMC: 11049100. DOI: 10.3390/cells13080720.

Role of a Pdlim5:PalmD complex in directing dendrite morphology.

Srivastava Y, Donta M, Mireles L, Paulucci-Holthauzen A, Waxham M, McCrea P Front Cell Neurosci. 2024; 18:1315941.

PMID: 38414752 PMC: 10896979. DOI: 10.3389/fncel.2024.1315941.

A novel effect of PDLIM5 in α7 nicotinic acetylcholine receptor upregulation and surface expression.

Li Z, Gou C, Wang W, Li Y, Cui Y, Duan J Cell Mol Life Sci. 2022; 79(1):64.

PMID: 35013841 PMC: 11072317. DOI: 10.1007/s00018-021-04115-y.

An Overview of the Cytoskeleton-Associated Role of PDLIM5.

Huang X, Qu R, Ouyang J, Zhong S, Dai J Front Physiol. 2020; 11:975.

PMID: 32848888 PMC: 7426503. DOI: 10.3389/fphys.2020.00975.

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