Effect of Feline Interferon-omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2008 Jan 17

PMID 18196725

Citations 64

Authors

Susanne Ritz

Herman Egberink

Katrin Hartmann

Affiliations

Soon will be listed here.

Abstract

Background: There is no therapy with proven efficacy to treat cats with feline infectious peritonitis (FIP).

Hypothesis: Feline interferon-omega (FeIFN-omega) prolongs survival time and increases quality of life in cats with FIP.

Animals: Thirty-seven privately owned cats were subjects of this study.

Methods: The study was performed as a placebo-controlled double-blind trial. Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either FeIFN-omega or a placebo. All cats received adjunctive treatment with glucocorticoids and antibiotics and passive immunization with Feliserin.

Results: There was no statistically significant difference in the survival time of cats treated with FeIFN-omega versus placebo or in any other variable evaluated (with the exception of the lymphocyte count). The cats survived between 3 and 200 days (median, 9 days). There was only 1 long-term survivor (> 3 months), and the cat was in the FeIFN-omega group.

Conclusion And Clinical Relevance: No effect of FeIFN-omega on survival time or quality of life could be demonstrated in this study.

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References

Ueda Y, Sakurai T, Kasama K, Satoh Y, Atsumi K, Hanawa S . Pharmacokinetic properties of recombinant feline interferon and its stimulatory effect on 2',5'-oligoadenylate synthetase activity in the cat. J Vet Med Sci. 1993; 55(1):1-6. DOI: 10.1292/jvms.55.1. View

Bertens A . [Passive and active immunization against feline enteritis and rhinotracheitis in experimental cats (author's transl)]. Tijdschr Diergeneeskd. 1979; 104(3):107-10. View

Benetka V, Kubber-Heiss A, Kolodziejek J, Nowotny N, Hofmann-Parisot M, Mostl K . Prevalence of feline coronavirus types I and II in cats with histopathologically verified feline infectious peritonitis. Vet Microbiol. 2004; 99(1):31-42. PMC: 7117137. DOI: 10.1016/j.vetmic.2003.07.010. View

Robison R, HOLZWORTH J, GILMORE C . Naturally occurring feline infectious peritonitis: signs and clinical diagnosis. J Am Vet Med Assoc. 1971; 158(6):Suppl 2:981-6. View

Pedersen N, Black J, Boyle J, Evermann J, McKeirnan A, OTT R . Pathogenic differences between various feline coronavirus isolates. Adv Exp Med Biol. 1984; 173:365-80. DOI: 10.1007/978-1-4615-9373-7_36. View

Weiss R . Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro. Vet Microbiol. 1989; 20(3):255-65. PMC: 7117261. DOI: 10.1016/0378-1135(89)90049-7. View

Hartmann K, Binder C, Hirschberger J, Cole D, Reinacher M, Schroo S . Comparison of different tests to diagnose feline infectious peritonitis. J Vet Intern Med. 2003; 17(6):781-90. PMC: 7197515. DOI: 10.1111/j.1939-1676.2003.tb02515.x. View

Ishida T, Shibanai A, Tanaka S, Uchida K, Mochizuki M . Use of recombinant feline interferon and glucocorticoid in the treatment of feline infectious peritonitis. J Feline Med Surg. 2004; 6(2):107-9. PMC: 7129501. DOI: 10.1016/j.jfms.2003.08.011. View

Kyuwa S, Tagawa Y, MACHII K, Shibata S, Doi K, Fujiwara K . MHV-induced fatal peritonitis in mice lacking IFN-gamma. Adv Exp Med Biol. 1998; 440:445-50. DOI: 10.1007/978-1-4615-5331-1_56. View

10.

Tammer R, Evensen O, Lutz H, Reinacher M . Immunohistological demonstration of feline infectious peritonitis virus antigen in paraffin-embedded tissues using feline ascites or murine monoclonal antibodies. Vet Immunol Immunopathol. 1995; 49(1-2):177-82. PMC: 7119862. DOI: 10.1016/0165-2427(95)05459-j. View

11.

Pedersen N . Virologic and immunologic aspects of feline infectious peritonitis virus infection. Adv Exp Med Biol. 1987; 218:529-50. DOI: 10.1007/978-1-4684-1280-2_69. View

12.

Weiss R, Cox N . Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random-source cats. Am J Vet Res. 1990; 51(5):726-33. View

13.

Dufour V, Millon L, Faucher J, Bard E, Robinet E, Piarroux R . Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans. Int Immunopharmacol. 2005; 5(5):917-28. DOI: 10.1016/j.intimp.2005.01.007. View

14.

Rohrbach B, Legendre A, Baldwin C, Lein D, Reed W, Wilson R . Epidemiology of feline infectious peritonitis among cats examined at veterinary medical teaching hospitals. J Am Vet Med Assoc. 2001; 218(7):1111-5. DOI: 10.2460/javma.2001.218.1111. View

15.

Hartmann K, Kuffer M . Karnofsky's score modified for cats. Eur J Med Res. 1998; 3(1-2):95-8. View

16.

Herrewegh A, Smeenk I, Horzinek M, Rottier P, de Groot R . Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus. J Virol. 1998; 72(5):4508-14. PMC: 109693. DOI: 10.1128/JVI.72.5.4508-4514.1998. View

17.

Brooks B, Hart C, Coleman J . Differential effects of beta-lactams on human IFN-gamma activity. J Antimicrob Chemother. 2005; 56(6):1122-5. DOI: 10.1093/jac/dki373. View

18.

Hohdatsu T, Okada S, Ishizuka Y, Yamada H, Koyama H . The prevalence of types I and II feline coronavirus infections in cats. J Vet Med Sci. 1992; 54(3):557-62. DOI: 10.1292/jvms.54.557. View

19.

Walter J, Rudolph R . [The frequency and pathogenesis of feline infectious peritonitis (FIP)]. Dtsch Tierarztl Wochenschr. 1989; 96(4):194-6, 201. View