Genome-wide Scan Identifies Variation in MLXIPL Associated with Plasma Triglycerides

Overview

Journal Nat Genet

Specialty Genetics

Date 2008 Jan 15

PMID 18193046

Citations 161

Authors

Jaspal S Kooner

John C Chambers

Carlos A Aguilar-Salinas

David A Hinds

Craig L Hyde

Gregory R Warnes

Francisco J Gomez Perez

Kelly A Frazer

Paul Elliott

James Scott

Patrice M Milos

David R Cox

John F Thompson

Affiliations

Soon will be listed here.

Abstract

We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a nonsynonymous SNP (rs3812316, G771C, Gln241His) in MLXIPL with plasma triglyceride levels (combined P = 1.4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'.

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