Role of Muscarinic Receptors in the Regulation of Immune and Inflammatory Responses

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2008 Jan 15

PMID 18190972

Citations 35

Authors

Seddigheh Razani-Boroujerdi

Muskaan Behl

Fletcher F Hahn

Juan Carlos Pena-Philippides

Julie Hutt

Mohan L Sopori

Affiliations

Soon will be listed here.

Abstract

Leukocytes contain both nicotinic and muscarinic receptors, and while activation of nicotinic receptors suppresses immune/inflammatory responses, the role of muscarinic receptors in immunity is unclear. We examined the effects of a muscarinic receptor antagonist (atropine) and agonist (oxotremorine), administered chronically through miniosmotic pumps, on immune/inflammatory responses in the rat. Results show that while oxotremorine stimulated, atropine inhibited the antibody and T-cell proliferative responses. Moreover, atropine also suppressed the turpentine-induced leukocytic infiltration and tissue injury, and inhibited chemotaxis of leukocytes toward neutrophil and monocyte/lymphocyte chemoattractants. Thus, activation of nicotinic and muscarinic receptors has opposite effects on the immune/inflammatory responses.

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