Genome-wide Expression Profiles of Endogenous Retroviruses in Lymphoid Tissues and Their Biological Properties

Overview

Journal Virology

Specialty Microbiology

Date 2008 Jan 12

PMID 18187179

Citations 13

Authors

Young-Kwan Lee

Alex Chew

Ho Phan

David G Greenhalgh

Kiho Cho

Affiliations

Soon will be listed here.

Abstract

Endogenous retroviruses (ERVs) constitute approximately 8-10% of the human and mouse genome. Some autoimmune diseases are attributed to the altered expression of ERVs. In this study, we examined the ERV expression profiles in lymphoid tissues and analyzed their biological properties. Tissues (spleen, thymus, and lymph nodes [axillary, inguinal, and mesenteric]) from C57BL/6J mice were analyzed for differential murine ERV (MuERV) expression by RT-PCR examination of polymorphic U3 sequences. Each tissue had a unique profile of MuERV expression. A genomic map identifying 60 putative MuERVs was established using 22 unique U3s as probes and their biological properties (primer binding site, coding potential, transcription regulatory element, tropism, recombination event, and integration age) were characterized. Interestingly, 12 putative MuERVs retained intact coding potentials for all three polypeptides essential for virus assembly and replication. We suggest that MuERV expression is differentially regulated in conjunction with the transcriptional environment of individual lymphoid tissues.

Citing Articles

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Evidence for the persistence of an active endogenous retrovirus (ERVE) in humans.

Naveira H, Bello X, Abal-Fabeiro J, Maside X Genetica. 2014; 142(5):451-60.

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Pathological and evolutionary implications of retroviruses as mobile genetic elements.

Hayes M, Whitesell M, Brown M Genes (Basel). 2014; 4(4):573-82.

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Divergent and dynamic activity of endogenous retroviruses in burn patients and their inflammatory potential.

Lee K, Rah H, Green T, Lee Y, Lim D, Nemzek J Exp Mol Pathol. 2014; 96(2):178-87.

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