Malignant Tumors and Chronic Infections in the Masticator Space: Preliminary Assessment with in Vivo Single-voxel 1H-MR Spectroscopy

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2008 Jan 11

PMID 18184844

Citations 5

Authors

Q Yu

J Yang

P Wang

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Differential diagnosis between malignant tumors and chronic infections in the masticator space remains challenging. The purpose of the study was to categorize various changes of both lesions by using single-voxel 1H-MR spectroscopy.

Materials And Methods: Twenty-four masticator space lesions, 7 chronic infections, and 17 malignant tumors were assessed with 1H-MR spectroscopy before treatment procedures. The MR spectroscopic findings were compared with surgical and histopathologic results. Localization technique for 1H-MR spectroscopy was made by a point-resolved spectroscopy sequence at an echo time of 144 ms. Choline (Cho) signals (identified at 3.2 ppm) and Cho signal intensity-to-noise ratio (Cho/noise) were considered as evaluating criteria.

Results: All the lesions were found with 3 1H-MR spectroscopic types: type 1, lesions without Cho signals (3 chronic infections); type 2, lesions with Cho signals and Cho/noise ratio <3 (4 chronic infections and 4 malignant tumors); and type 3, lesions with Cho signals and Cho/noise ratio >3 (13 malignant tumors). The mean +/- SD of the Cho/noise ratio between chronic infections and malignant tumors was 2.31 +/- 0.19 and 5.76 +/- 3.29 (P < .01), respectively.

Conclusion: In vivo single-voxel 1H-MR spectroscopy may be helpful in the assessment of masticator space lesions. Differences of Cho signals and Cho/noise ratios between malignant tumors and chronic infections provide valuable information in the differentiation of these 2 lesions.

Citing Articles

Tuberculosis of the parotid lymph nodes: clinical and imaging features.

Zhang D, Li X, Xiong H, Yang C, Lv F, Huang X Infect Drug Resist. 2018; 11:1795-1805.

PMID: 30349336 PMC: 6188200. DOI: 10.2147/IDR.S164993.

A minimum-phase Shinnar-Le Roux spectral-spatial excitation RF pulse for simultaneous water and lipid suppression in H-MRSI of body extremities.

Han P, Ma C, Deng K, Hu S, Jee K, Ying K Magn Reson Imaging. 2017; 45:18-25.

PMID: 28917812 PMC: 5709164. DOI: 10.1016/j.mri.2017.09.008.

Computed tomography and magnetic resonance imaging of lesions at masticator space.

Razek A Jpn J Radiol. 2014; 32(3):123-37.

PMID: 24500138 DOI: 10.1007/s11604-014-0289-x.

Anatomy and pathology of the masticator space.

Fernandes T, Lobo J, Castro R, Oliveira M, Som P Insights Imaging. 2013; 4(5):605-16.

PMID: 23888350 PMC: 3781239. DOI: 10.1007/s13244-013-0266-4.

Role of diffusion-weighted MRI in differentiation of masticator space malignancy from infection.

Abdel Razek A, Nada N Dentomaxillofac Radiol. 2013; 42(4):20120183.

PMID: 23420858 PMC: 3667512. DOI: 10.1259/dmfr.20120183.

References

Mukherji S, Schiro S, Castillo M, Kwock L, Muller K, Blackstock W . Proton MR spectroscopy of squamous cell carcinoma of the extracranial head and neck: in vitro and in vivo studies. AJNR Am J Neuroradiol. 1997; 18(6):1057-72. PMC: 8337295. View

Shah G, Gandhi D, Mukherji S . Magnetic resonance spectroscopy of head and neck neoplasms. Top Magn Reson Imaging. 2004; 15(2):87-94. DOI: 10.1097/01.rmr.0000130599.19502.ba. View

Star-Lack J, Adalsteinsson E, Adam M, Terris D, Pinto H, Brown J . In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements. AJNR Am J Neuroradiol. 2000; 21(1):183-93. PMC: 7976356. View

Scher R, Ropka M, Neal D, Berr S, Trouard T, Deutsch B . NMR spectroscopy evaluation of plasma "oncolipids" in head and neck cancer. Otolaryngol Head Neck Surg. 1990; 102(1):34-40. DOI: 10.1177/019459989010200106. View

Maheshwari S, Mukherji S, Neelon B, Schiro S, Fatterpekar G, Stone J . The choline/creatine ratio in five benign neoplasms: comparison with squamous cell carcinoma by use of in vitro MR spectroscopy. AJNR Am J Neuroradiol. 2000; 21(10):1930-5. PMC: 7974295. View

Mafee M, Barany M, Gotsis E, DOBBEN G, Puklin J, Chow J . Potential use of in vivo proton spectroscopy for head and neck lesions. Radiol Clin North Am. 1989; 27(2):243-54. View

King A, Yeung D, Ahuja A, Yuen E, Ho S, Tse G . Human cervical lymphadenopathy: evaluation with in vivo 1H-MRS at 1.5 T. Clin Radiol. 2005; 60(5):592-8. DOI: 10.1016/j.crad.2004.11.012. View

Chow J, Gotsis E, Jarc M, Dillon J, Wyrwicz A, Applebaum E . Proton nuclear magnetic resonance spectroscopy of plasma lipoproteins in head and neck cancer patients. Am J Otolaryngol. 1990; 11(5):332-8. DOI: 10.1016/0196-0709(90)90064-3. View

Schwarz A, Maisey N, Collins D, Cunningham D, Huddart R, Leach M . Early in vivo detection of metabolic response: a pilot study of 1H MR spectroscopy in extracranial lymphoma and germ cell tumours. Br J Radiol. 2003; 75(900):959-66. DOI: 10.1259/bjr.75.900.750959. View

10.

De Vuysere S, Hermans R, Sciot R, Crevits I, Marchal G . Extraorbital inflammatory pseudotumor of the head and neck: CT and MR findings in three patients. AJNR Am J Neuroradiol. 1999; 20(6):1133-9. PMC: 7056226. View

11.

Dawson D, Sekhar V, Pearson G, Vaickus L . Nuclear magnetic resonance spectroscopy of plasma for the detection of head and neck cancer. Am J Otolaryngol. 1989; 10(4):244-9. DOI: 10.1016/0196-0709(89)90003-3. View

12.

Bartella L, Morris E, Dershaw D, Liberman L, Thakur S, Moskowitz C . Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study. Radiology. 2006; 239(3):686-92. DOI: 10.1148/radiol.2393051046. View

13.

King A, Yeung D, Ahuja A, Tse G, Yuen H, Wong K . Salivary gland tumors at in vivo proton MR spectroscopy. Radiology. 2005; 237(2):563-9. DOI: 10.1148/radiol.2372041309. View

14.

King A, Yeung D, Ahuja A, Tse G, Chan A, Lam S . In vivo 1H MR spectroscopy of thyroid carcinoma. Eur J Radiol. 2005; 54(1):112-7. DOI: 10.1016/j.ejrad.2004.05.003. View

15.

Bisdas S, Baghi M, Huebner F, Mueller C, Knecht R, Vorbuchner M . In vivo proton MR spectroscopy of primary tumours, nodal and recurrent disease of the extracranial head and neck. Eur Radiol. 2006; 17(1):251-7. DOI: 10.1007/s00330-006-0294-2. View

16.

Bezabeh T, Odlum O, Nason R, Kerr P, Sutherland D, Patel R . Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. AJNR Am J Neuroradiol. 2005; 26(8):2108-13. PMC: 8148844. View

17.

King A, Yeung D, Ahuja A, Leung S, Tse G, Van Hasselt A . In vivo proton MR spectroscopy of primary and nodal nasopharyngeal carcinoma. AJNR Am J Neuroradiol. 2004; 25(3):484-90. PMC: 8158563. View

18.

Wang C, Li C, Hsieh T, Chien S, Liu G, Tsai K . Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy: initial results. Radiology. 2004; 232(2):599-605. DOI: 10.1148/radiol.2322031441. View

19.

Lee J, Yamaguchi T, Abe A, Shizukuishi K, Uemura H, Miyagi E . Clinical evaluation of choline measurement by proton MR spectroscopy in patients with malignant tumors. Radiat Med. 2004; 22(3):148-54. View

20.

Ruiz-Cabello J, Cohen J . Phospholipid metabolites as indicators of cancer cell function. NMR Biomed. 1992; 5(5):226-33. DOI: 10.1002/nbm.1940050506. View