» Articles » PMID: 1818389

Clinical Trial of Artesunate and Artemether on Multidrug Resistant Falciparum Malaria in Thailand. A Preliminary Report

Overview
Specialty Public Health
Date 1991 Sep 1
PMID 1818389
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

A 5-day course of oral artesunate at total doses of 1200, 600, 650 mg and intramuscular artemether 480 mg proved effective (90-100% cured) in the treatment of multidrug resistant falciparum malaria in Thailand. Shorter courses yielded high recrudescence rates. The fever clearance and parasite clearance times were short. The side effects were mild and transient including occasional abnormal electrocardiograms and pain at the injection site. Slight reduction of neutrophil leucocytes and reticulocytes was observed. Further studies of artesunate and artemether should be carried out to find the optimum dosage regimen and to clarify the hematological effects.

Citing Articles

Efficacy of artemether against toxocariasis in mice: parasitological and immunopathological changes in brain, liver, and lung.

Elgendy D, Elmahy R, Amer A, Ibrahim H, Eltantawy A, Mansour F Pathog Glob Health. 2023; 118(1):47-64.

PMID: 37978995 PMC: 10769145. DOI: 10.1080/20477724.2023.2285182.


New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells.

Lin L, Tang Z, Shi Z, Guo Q, Xiong H J Immunol Res. 2022; 2022:9591544.

PMID: 35178460 PMC: 8844150. DOI: 10.1155/2022/9591544.


Advances in the research on the targets of anti-malaria actions of artemisinin.

Yang J, He Y, Li Y, Zhang X, Wong Y, Shen S Pharmacol Ther. 2020; 216:107697.

PMID: 33035577 PMC: 7537645. DOI: 10.1016/j.pharmthera.2020.107697.


Origin and Spread of Evolving Artemisinin-Resistant Malarial Parasites in Southeast Asia.

Hassett M, Roepe P Am J Trop Med Hyg. 2019; 101(6):1204-1211.

PMID: 31642425 PMC: 6896886. DOI: 10.4269/ajtmh.19-0379.


Split dosing of artemisinins does not improve antimalarial therapeutic efficacy.

White N, Watson J, Ashley E Sci Rep. 2017; 7(1):12132.

PMID: 28935919 PMC: 5608907. DOI: 10.1038/s41598-017-12483-4.