Article: The importance of valid disclosures in the human embryonic stem cell research debate

Misinformation erodes the legitimacy of any public debate. Since the start of human embryonic stem cell research deliberations in the USA, misinformation concerning the nature of human embryos, their availability for research, and the potential for using them to develop new medical therapies have been widespread and persistent. Basic facts, well understood by physicians and biologists, have been so misstated and misrepresented in the news media and political speeches that the general public has been put in a state of constant uncertainty. The solution to the present troubling condition is better education in the form of diligent, honest, and complete scientific disclosure by responsible scientists and physicians; and more care given to accurate reporting by news media. Several key aspects of newly emerging embryonic and non-embryonic stem cell technologies are defined and discussed as they relate to the debate over the use of human embryos for medical research. An important topic for consideration is how to disclose with clarity the scientific basis for human embryonic life. Thereafter, failings in proposed technologies for developing new therapies with human embryonic stem cells, that have been grossly under-reported, are examined. Finally, properties of adult stem cells are presented in contradistinction to embryonic stem cells, both in terms of adult stem cells as a scientifically better alternative to embryonic stem cells and in terms of the technological challenges that must be overcome to realize the potential of adult stem cells for new medical therapies.

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References

1.

Lee H, Sherley J, Chen J, Chiu C, Chiou L, Liang J . EMP-1 is a junctional protein in a liver stem cell line and in the liver. Biochem Biophys Res Commun. 2005; 334(4):996-1003. DOI: 10.1016/j.bbrc.2005.06.194. View

2.

Rambhatla L, Ram-Mohan S, Cheng J, Sherley J . Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Res. 2005; 65(8):3155-61. DOI: 10.1158/0008-5472.CAN-04-3161. View

3.

McArthur S, Leigh D, Marshall J, de Boer K, Jansen R . Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertil Steril. 2005; 84(6):1628-36. DOI: 10.1016/j.fertnstert.2005.05.063. View

4.

Semino C, Merok J, Crane G, Panagiotakos G, Zhang S . Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation. 2003; 71(4-5):262-70. DOI: 10.1046/j.1432-0436.2003.7104503.x. View

5.

Klimanskaya I, Chung Y, Becker S, Lu S, Lanza R . Human embryonic stem cell lines derived from single blastomeres. Nature. 2006; 444(7118):481-5. DOI: 10.1038/nature05142. View

6.

Rambhatla L, Bohn S, Stadler P, Boyd J, Coss R, Sherley J . Cellular Senescence: Ex Vivo p53-Dependent Asymmetric Cell Kinetics. J Biomed Biotechnol. 2002; 1(1):28-37. PMC: 79675. DOI: 10.1155/S1110724301000079. View

7.

Lee H, Crane G, Merok J, Tunstead J, Hatch N, Panchalingam K . Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK). Biotechnol Bioeng. 2003; 83(7):760-71. DOI: 10.1002/bit.10727. View

8.

Sherley J . Human Embryonic Stem Cell Research: No Way Around a Scientific Bottleneck. J Biomed Biotechnol. 2004; 2004(2):71-72. PMC: 548808. DOI: 10.1155/S1110724304403118. View

9.

Sherley J . Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells. 2002; 20(6):561-72. DOI: 10.1634/stemcells.20-6-561. View

10.

Merok J, Sherley J . Breaching the Kinetic Barrier to In Vitro Somatic Stem Cell Propagation. J Biomed Biotechnol. 2002; 1(1):25-27. PMC: 79674. DOI: 10.1155/S1110724301000067. View

11.

Hoffman D, Zellman G, Fair C, Mayer J, Zeitz J, Gibbons W . Cryopreserved embryos in the United States and their availability for research. Fertil Steril. 2003; 79(5):1063-9. DOI: 10.1016/s0015-0282(03)00172-9. View

12.

Potten C, Morris R . Epithelial stem cells in vivo. J Cell Sci Suppl. 1988; 10:45-62. DOI: 10.1242/jcs.1988.supplement_10.4. View

The Importance of Valid Disclosures in the Human Embryonic Stem Cell Research Debate