Gene Therapy for Arthritis

Overview

Journal Mod Rheumatol

Publisher Oxford University Press

Specialty Rheumatology

Date 2008 Jan 8

PMID 18176779

Citations 6

Authors

Russell S Traister

Raphael Hirsch

Affiliations

Soon will be listed here.

Abstract

Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by short half-lives of the drugs and the requirement for repeated systemic administration. Utilizing gene transfer approaches for the treatment of arthritis may overcome some of the obstacles associated with current treatment strategies. The present review examines recent developments in gene therapy for arthritis. Delivery strategies, gene transfer vectors, candidate genes, and safety are also discussed.

Citing Articles

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Cytokine-modulating strategies and newer cytokine targets for arthritis therapy.

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Immunosuppressive exosomes: a new approach for treating arthritis.

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Getting arthritis gene therapy into the clinic.

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