Origins of Barriers and Barrierless Folding in BBL

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2008 Jan 4

PMID 18172203

Citations 46

Authors

Samuel S Cho

Patrick Weinkam

Peter G Wolynes

Affiliations

Soon will be listed here.

Abstract

In contrast to classical chemical phenomenology, theory suggests that proteins may undergo downhill folding without an activation barrier under certain thermodynamic conditions. Recently, the BBL protein was proposed to fold by such a downhill scenario, but discrepancies between experimental results found in different groups argue against this. After briefly reviewing the major experimental studies of the BBL folding mechanism, we show that simulations of both coarse-grained and atomistic models can reconcile the seemingly conflicting observations.

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