In Vivo Voltammetric Studies on Release Mechanisms for Cocaine with Gamma-butyrolactone

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 1991 Dec 1

PMID 1816583

Citations 13

Authors

P A Broderick

Affiliations

Soon will be listed here.

Abstract

The effect of cocaine (20 mg/kg SC) on presynaptic mechanisms of release for dopamine (DA) and for serotonin (5-HT) was studied in nucleus accumbens of unrestrained rats (Rattus norvegicus). The studies were done by assaying synaptic concentrations of DA and 5-HT in the presence of the neuronal impulse flow inhibitor, gamma-butyrolactone (gamma-BL). The results were compared with cocaine effects on accumbens DA and 5-HT in the freely moving rat, without gamma-BL treatment. A neurochemical time course profile showed that the cocaine-induced increase in accumbens synaptic concentrations of DA was significantly blocked (p less than 0.0001) after DA impulse flow was significantly inhibited (p less than 0.0038) by gamma-BL (35.8%). The neurochemical time course profile concurrently showed that the cocaine-induced decrease in accumbens synaptic concentrations of 5-HT was significantly blocked (p less than 0.0004) after impulse flow was significantly inhibited (p less than 0.025) by gamma-BL (50.6%). The findings show that cocaine's effects on synaptic concentrations for DA and for 5-HT in accumbens are dependent on neuronal impulse flow. The findings indicate that presynaptic releasing mechanisms, which may be different for DA vis-à-vis 5-HT, play a role in the mechanism of action of cocaine.

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