Treatment of Infected Hip Arthroplasty with Antibiotic-impregnated Calcium Hydroxyapatite

Overview

Journal J Arthroplasty

Specialty Orthopedics

Date 2008 Jan 1

PMID 18165045

Citations 11

Authors

Akihiro Sudo

Masahiro Hasegawa

Aki Fukuda

Atsumasa Uchida

Affiliations

Soon will be listed here.

Abstract

We reviewed the treatment of infected hip arthroplasty with antibiotic-impregnated calcium hydroxyapatite (CHA) ceramic blocks. Seven consecutive patients consisting of 2 men and 5 women with an average age of 65 years were followed up for an average of 5.0 years. All patients received resection arthroplasty and thorough debridement, followed by implantation of antibiotic-impregnated CHA ceramic. Two-stage revision was performed in all patients. There was no evidence of a recurrent infection in 6 patients. The remaining one patient underwent an additional debridement 2 years after the second stage. This patient was free of infection at the time of the latest follow-up. Antibiotic-impregnated CHA ceramic is thus considered to be an excellent drug delivery system for the infected hip arthroplasty.

Citing Articles

Determining Hydroxyapatite Filling Volume for the Treatment of Post-Extraction Alveoli Based on Measurements of Alveolar Volume in Relation to the Body Weight of Dogs.

Misztal-Kunecka A, Przadka P, Jez M, Dzimira S Vet Sci. 2024; 11(12).

PMID: 39728973 PMC: 11680159. DOI: 10.3390/vetsci11120633.

Long-Term Outcome of Treating Periprosthetic Hip Joint Infection with Local Antibiotics Delivered Through Antibiotic-Impregnated Calcium Hydroxyapatite.

Wakabayashi H, Hasegawa M, Naito Y, Tone S, Sudo A J Clin Med. 2024; 13(23).

PMID: 39685927 PMC: 11642245. DOI: 10.3390/jcm13237469.

Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model of -Induced Periprosthetic Joint Infection.

Markel D, Powell D, Wu B, Paula Pawlitz , Bou-Akl T, Chen L Int J Mol Sci. 2024; 25(14).

PMID: 39063169 PMC: 11276967. DOI: 10.3390/ijms25147926.

Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study.

Jiamton C, Apivatgaroon A, Aunaramwat S, Chawalitrujiwong B, Chuaychoosakoon C, Suwannaphisit S Antibiotics (Basel). 2023; 12(6).

PMID: 37370370 PMC: 10295329. DOI: 10.3390/antibiotics12061049.

Outcome of Irrigation and Debridement with Topical Antibiotic Delivery Using Antibiotic-Impregnated Calcium Hydroxyapatite for the Management of Periprosthetic Hip Joint Infection.

Wakabayashi H, Hasegawa M, Naito Y, Tone S, Sudo A Antibiotics (Basel). 2023; 12(5).

PMID: 37237841 PMC: 10215927. DOI: 10.3390/antibiotics12050938.