JAK-STAT Pathway in Carcinogenesis: is It Relevant to Cholangiocarcinoma Progression?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Dec 29

PMID 18161917

Citations 13

Authors

Olga V Smirnova

Tatiana Yu Ostroukhova

Roman L Bogorad

Affiliations

Soon will be listed here.

Abstract

The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.

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