Infectious Disease: Connecting Innate Immunity to Biocidal Polymers

Overview

Journal Mater Sci Eng R Rep

Date 2007 Dec 28

PMID 18160969

Citations 55

Authors

Gregory J Gabriel

Abhigyan Som

Ahmad E Madkour

Tarik Eren

Gregory N Tew

Affiliations

Soon will be listed here.

Abstract

Infectious disease is a critically important global healthcare issue. In the U.S. alone there are 2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 billion dollars of added healthcare costs. Couple these numbers with the appearance of new antibiotic resistant bacterial strains and the increasing occurrences of community-type outbreaks, and clearly this is an important problem. Our review attempts to bridge the research areas of natural host defense peptides (HDPs), a component of the innate immune system, and biocidal cationic polymers. Recently discovered peptidomimetics and other synthetic mimics of HDPs, that can be short oligomers as well as polymeric macromolecules, provide a unique link between these two areas. An emerging class of these mimics are the facially amphiphilic polymers that aim to emulate the physicochemical properties of HDPs but take advantage of the synthetic ease of polymers. These mimics have been designed with antimicrobial activity and, importantly, selectivity that rivals natural HDPs. In addition to providing some perspective on HDPs, selective mimics, and biocidal polymers, focus is given to the arsenal of biophysical techniques available to study their mode of action and interactions with phospholipid membranes. The issue of lipid type is highlighted and the important role of negative curvature lipids is illustrated. Finally, materials applications (for instance, in the development of permanently antibacterial surfaces) are discussed as this is an important part of controlling the spread of infectious disease.

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References

Bechinger B . The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim Biophys Acta. 1999; 1462(1-2):157-83. DOI: 10.1016/s0005-2736(99)00205-9. View

Hong S, Leroueil P, Janus E, Peters J, Kober M, Islam M . Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. Bioconjug Chem. 2006; 17(3):728-34. DOI: 10.1021/bc060077y. View

Hetrick E, Schoenfisch M . Reducing implant-related infections: active release strategies. Chem Soc Rev. 2006; 35(9):780-9. DOI: 10.1039/b515219b. View

Arvidsson P, Frackenpohl J, Ryder N, Liechty B, Petersen F, Zimmermann H . On the antimicrobial and hemolytic activities of amphiphilic beta-peptides. Chembiochem. 2002; 2(10):771-3. DOI: 10.1002/1439-7633(20011001)2:10<771::aid-cbic771>3.0.co;2-#. View

Lin J, Qiu S, Lewis K, Klibanov A . Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. Biotechnol Bioeng. 2003; 83(2):168-72. DOI: 10.1002/bit.10651. View

Beschiaschvili G, Seelig J . Melittin binding to mixed phosphatidylglycerol/phosphatidylcholine membranes. Biochemistry. 1990; 29(1):52-8. DOI: 10.1021/bi00453a007. View

Ishitsuka Y, Arnt L, Majewski J, Frey S, Ratajczek M, Kjaer K . Amphiphilic poly(phenyleneethynylene)s can mimic antimicrobial peptide membrane disordering effect by membrane insertion. J Am Chem Soc. 2006; 128(40):13123-9. DOI: 10.1021/ja061186q. View

Dubovskii P, Volynsky P, Polyansky A, Chupin V, Efremov R, Arseniev A . Spatial structure and activity mechanism of a novel spider antimicrobial peptide. Biochemistry. 2006; 45(35):10759-67. DOI: 10.1021/bi060635w. View

Chen F, Lee M, Huang H . Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation. Biophys J. 2003; 84(6):3751-8. PMC: 1302957. DOI: 10.1016/S0006-3495(03)75103-0. View

10.

Rennie J, Arnt L, Tang H, Nusslein K, Tew G . Simple oligomers as antimicrobial peptide mimics. J Ind Microbiol Biotechnol. 2005; 32(7):296-300. DOI: 10.1007/s10295-005-0219-0. View

11.

Heller W, Waring A, Lehrer R, Harroun T, Weiss T, Yang L . Membrane thinning effect of the beta-sheet antimicrobial protegrin. Biochemistry. 2000; 39(1):139-45. DOI: 10.1021/bi991892m. View

12.

LEWIS R, Winter I, Kriechbaum M, Lohner K, McElhaney R . Studies of the structure and organization of cationic lipid bilayer membranes: calorimetric, spectroscopic, and x-ray diffraction studies of linear saturated P-O-ethyl phosphatidylcholines. Biophys J. 2001; 80(3):1329-42. PMC: 1301325. DOI: 10.1016/S0006-3495(01)76106-1. View

13.

Prenner E, Kay C, McElhaney R, Hodges R . Conformation and interaction of the cyclic cationic antimicrobial peptides in lipid bilayers. J Pept Res. 2002; 60(1):23-36. DOI: 10.1034/j.1399-3011.2002.21003.x. View

14.

Glukhov E, Stark M, Burrows L, Deber C . Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes. J Biol Chem. 2005; 280(40):33960-7. DOI: 10.1074/jbc.M507042200. View

15.

Weiss T, Yang L, Ding L, Waring A, Lehrer R, Huang H . Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers. Biochemistry. 2002; 41(31):10070-6. DOI: 10.1021/bi025853d. View

16.

Lee S, Koepsel R, Stolz D, Warriner H, Russell A . Self-assembly of biocidal nanotubes from a single-chain diacetylene amine salt. J Am Chem Soc. 2004; 126(41):13400-5. DOI: 10.1021/ja048463i. View

17.

Yang L, Harroun T, Heller W, Weiss T, Huang H . Neutron off-plane scattering of aligned membranes. I. Method Of measurement. Biophys J. 1998; 75(2):641-5. PMC: 1299739. DOI: 10.1016/S0006-3495(98)77554-X. View

18.

Ignatova M, Voccia S, Gilbert B, Markova N, Mercuri P, Galleni M . Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization. Langmuir. 2004; 20(24):10718-26. DOI: 10.1021/la048347t. View

19.

Hong M . Oligomeric structure, dynamics, and orientation of membrane proteins from solid-state NMR. Structure. 2006; 14(12):1731-40. DOI: 10.1016/j.str.2006.10.002. View

20.

Lohner K, Prenner E . Differential scanning calorimetry and X-ray diffraction studies of the specificity of the interaction of antimicrobial peptides with membrane-mimetic systems. Biochim Biophys Acta. 1999; 1462(1-2):141-56. DOI: 10.1016/s0005-2736(99)00204-7. View