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Effect of Piperine on Bioavailability and Pharmacokinetics of Propranolol and Theophylline in Healthy Volunteers

Overview
Journal Eur J Clin Pharmacol
Specialty Pharmacology
Date 1991 Jan 1
PMID 1815977
Citations 35
Authors
G Bano
R K Raina
U Zutshi
K L Bedi
R K Johri
S C Sharma
Affiliations
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Abstract

The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.

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