Molecular Basis for Skeletal Variation: Insights from Developmental Genetic Studies in Mice

Overview

Journal Birth Defects Res B Dev Reprod Toxicol

Date 2007 Dec 25

PMID 18157899

Citations 3

Authors

C Kappen

A Neubuser

R Balling

R Finnell

Affiliations

Soon will be listed here.

Abstract

Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development.

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