Matricellular Molecules and Odontoblast Progenitors As Tools for Dentin Repair and Regeneration

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2007 Dec 25

PMID 18157557

Citations 10

Authors

M Goldberg

S Lacerda-Pinheiro

F Priam

N Jegat

N Six

M Bonnefoix

D Septier

C Chaussain-Miller

A Veis

P DenBesten

A Poliard

Affiliations

Soon will be listed here.

Abstract

This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.

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