Special Regulatory T-cell Review: Regulation of Immune Responses--examining the Role of T Cells

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2007 Dec 25

PMID 18154613

Citations 6

Authors

Elizabeth Simpson

Affiliations

Soon will be listed here.

Abstract

The history of regulatory T cells goes back to the realisation that T cells could provide 'help' for antibody responses: the obverse of this is their ability to hold them in check. This brief personal overview follows the initial designation of T cells as 'suppressor' and the various hypotheses, some now disproved, put forward for their mechanism of action. We now cautiously label them T regulatory cells, but realise they do not control not all immune regulation. They probably operate through several mechanisms, and some of these are discussed.

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References

Kontiainen S, Simpson E, Bohrer E, Beverley P, Herzenberg L, Fitzpatrick W . T-cell lines producing antigen-specific suppressor factor. Nature. 1978; 274(5670):477-80. DOI: 10.1038/274477a0. View

Hurme M, Hetherington C, Chandler P, Simpson E . Cytotoxic T-cell responses to H-Y: mapping of the Ir genes. J Exp Med. 1978; 147(3):758-67. PMC: 2184193. DOI: 10.1084/jem.147.3.758. View

Ptak W, Green D, Durum S, Kimura A, Murphy D, GERSHON R . Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: contrasuppressor cells can convert an in vivo tolerogenic signal into an immunogenic one. Eur J Immunol. 1981; 11(12):980-3. DOI: 10.1002/eji.1830111206. View

Kronenberg M, Kraig E, Siu G, Kapp J, Kappler J, Marrack P . Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts. J Exp Med. 1983; 158(1):210-27. PMC: 2187070. DOI: 10.1084/jem.158.1.210. View

Kronenberg M, Steinmetz M, Kobori J, Kraig E, Kapp J, Pierce C . RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1983; 80(18):5704-8. PMC: 384327. DOI: 10.1073/pnas.80.18.5704. View

Wildin R, Ramsdell F, Peake J, Faravelli F, Casanova J, Buist N . X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001; 27(1):18-20. DOI: 10.1038/83707. View

Brunkow M, Jeffery E, Hjerrild K, Paeper B, Clark L, Yasayko S . Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001; 27(1):68-73. DOI: 10.1038/83784. View

Choi E, Yoshimura Y, Christianson G, Sproule T, Malarkannan S, Shastri N . Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. J Immunol. 2001; 166(7):4370-9. DOI: 10.4049/jimmunol.166.7.4370. View

Waldmann H, Cobbold S . Regulating the immune response to transplants. a role for CD4+ regulatory cells?. Immunity. 2001; 14(4):399-406. DOI: 10.1016/s1074-7613(01)00120-0. View

10.

Fontenot J, Gavin M, Rudensky A . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003; 4(4):330-6. DOI: 10.1038/ni904. View

11.

Monk N, Hargreaves R, Marsh J, Farrar C, Sacks S, Millrain M . Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med. 2003; 9(10):1275-80. DOI: 10.1038/nm931. View

12.

Mitchison N . The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis. Eur J Immunol. 1971; 1(1):10-7. DOI: 10.1002/eji.1830010103. View

13.

Stockinger B, Kassiotis G, Bourgeois C . Homeostasis and T cell regulation. Curr Opin Immunol. 2004; 16(6):775-9. DOI: 10.1016/j.coi.2004.09.003. View

14.

Chaperon E, SELNER J, Claman H . Migration of antibody-forming cells and antigen-sensitive precursors between spleen, thymus and bone marrow. Immunology. 1968; 14(4):553-61. PMC: 1409391. View

15.

McDevitt H, TYAN M . Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus. J Exp Med. 1968; 128(1):1-11. PMC: 2138514. View

16.

Mitchell G, Miller J . Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med. 1968; 128(4):821-37. PMC: 2138546. DOI: 10.1084/jem.128.4.821. View

17.

GERSHON R, Kondo K . Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology. 1970; 18(5):723-37. PMC: 1455602. View

18.

GERSHON R, Kondo K . Infectious immunological tolerance. Immunology. 1971; 21(6):903-14. PMC: 1408252. View

19.

CANTOR H, Asofsky R . Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells. J Exp Med. 1972; 135(4):764-79. PMC: 2139160. DOI: 10.1084/jem.135.4.764. View

20.

Healy C, Kapp J, Webb D . Purification and biochemical analysis of antigen-specific suppressor factors obtained from the supernatant, membrane, or cytosol of a T cell hybridoma. J Immunol. 1983; 131(6):2843-7. View