Analysis of Pressure-driven Air Bubble Elimination in a Microfluidic Device

Overview

Journal Lab Chip

Publisher Royal Society of Chemistry

Specialties Biotechnology
Chemistry

Date 2007 Dec 21

PMID 18094777

Citations 28

Authors

Joo H Kang

Yu Chang Kim

Je-Kyun Park

Affiliations

Soon will be listed here.

Abstract

We report an analysis of pressure-driven bubble elimination for a gas-permeable microfluidic device. In this study, we described bubble elimination in a microfluidic device employing a gas permeation model and calculated the removal efficiency of bubbles. The correction factor for the simplified model was estimated with respect to the applied pressure. Based on the established model, the required time to remove a trapped bubble with a certain area was shown to be within an error of 11.58% by comparison with experimental results. Exploiting the model equation, we were able to completely remove the air bubbles appearing during the process of filling a microfluidic device with an aqueous solution.

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