Stem Cells in Airway Smooth Muscle: State of the Art

Overview

Journal Proc Am Thorac Soc

Specialty Pulmonary Medicine

Date 2007 Dec 21

PMID 18094079

Citations 14

Authors

Jaime Murphy

Ross Summer

Alan Fine

Affiliations

Soon will be listed here.

Abstract

Very little is known regarding the function, origin, and turnover of airway smooth muscle (ASM). In this article, we discuss the embryological development of ASM, and provide information regarding candidate mesenchymal ASM progenitor cell populations specifically in relation to airway remodeling. This review also highlights the current limitations in studying ASM biology, and underscores the need for novel molecular tools and markers that will refine our understanding of this cell type in lung homeostasis and disease.

Citing Articles

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts.

Luo Y, Cao K, Chiu J, Chen H, Wang H, Thornton M Elife. 2024; 12.

PMID: 38856718 PMC: 11164533. DOI: 10.7554/eLife.91876.

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts.

Luo Y, Cao K, Chiu J, Chen H, Wang H, Thornton M bioRxiv. 2023; .

PMID: 37808788 PMC: 10557633. DOI: 10.1101/2023.09.26.559527.

Sexual Dimorphism in the Regulation of Estrogen, Progesterone, and Androgen Receptors by Sex Steroids in the Rat Airway Smooth Muscle Cells.

Zarazua A, Gonzalez-Arenas A, Ramirez-Velez G, Bazan-Perkins B, Guerra-Araiza C, Campos-Lara M Int J Endocrinol. 2016; 2016:8423192.

PMID: 27110242 PMC: 4823480. DOI: 10.1155/2016/8423192.

Functional Effects of WNT1-Inducible Signaling Pathway Protein-1 on Bronchial Smooth Muscle Cell Migration and Proliferation in OVA-Induced Airway Remodeling.

Yang M, Du Y, Xu Z, Jiang Y Inflammation. 2015; 39(1):16-29.

PMID: 26242865 DOI: 10.1007/s10753-015-0218-x.

ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.

Marriott S, Baskir R, Gaskill C, Menon S, Carrier E, Williams J Am J Physiol Cell Physiol. 2014; 307(8):C684-98.

PMID: 25122876 PMC: 4200000. DOI: 10.1152/ajpcell.00114.2014.

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