Fluorescence of Non-neoplastic, Magnetic Resonance Imaging-enhancing Tissue by 5-aminolevulinic Acid: Case Report

Overview

Journal Neurosurgery

Specialty Neurosurgery

Date 2007 Dec 20

PMID 18091261

Citations 23

Authors

Shin-Ichi Miyatake

Toshihiko Kuroiwa

Yoshinaga Kajimoto

Minoru Miyashita

Hidekazu Tanaka

Motomu Tsuji

Affiliations

Soon will be listed here.

Abstract

Objective: It has been established that fluorescence-guided resection using 5-aminolevulinic acid is useful in glioma surgery. In this study, we describe three cases in which even perinecrotic tissue could be recognized as fluorescence positive.

Methods: Three cases of central nervous system disease, showing gadolinium enhancement on magnetic resonance imaging scans, were operated on with the aid of fluorescence derived from 5-aminolevulinic acid. Two of these were diagnosed as radiation necrosis and the other as a neurodegenerative demyelinating disease.

Results: In all cases, at least some parts of the gadolinium-enhanced area could be labeled as fluorescence positive, whereas centers of necrotic tissue were negative for fluorescence. Histologically, cell infiltration was marked in each case that showed fluorescence activity.

Conclusion: Both malignant tumors and the perinecrotic area in radiation necrosis or neurodegenerative disease can be labeled as fluorescence positive using 5-aminolevulinic acid.

Citing Articles

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5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series.

Duarte J, Jung G, da Silva Jr E, de Almeida Teixeira B, Cavalcanti M, Ramina R Neurosurg Rev. 2022; 45(5):3139-3148.

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5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.

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Accumulation of Uroporphyrin I in Necrotic Tissues of Squamous Cell Carcinoma after Administration of 5-Aminolevulinic Acid.

Beika M, Harada Y, Minamikawa T, Yamaoka Y, Koizumi N, Murayama Y Int J Mol Sci. 2021; 22(18).

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Fluorescence-Guided Surgery for High-Grade Gliomas: State of the Art and New Perspectives.

Palmieri G, Cofano F, Salvati L, Monticelli M, Zeppa P, Di Perna G Technol Cancer Res Treat. 2021; 20:15330338211021605.

PMID: 34212784 PMC: 8255554. DOI: 10.1177/15330338211021605.