Dysregulation of Dopamine-dependent Mechanisms As a Determinant of Hypertension: Studies in Dopamine Receptor Knockout Mice

Overview

Journal Am J Physiol Heart Circ Physiol

Publisher American Physiological Society

Specialties Cardiology & Vascular Diseases
Physiology

Date 2007 Dec 18

PMID 18083900

Citations 48

Authors

Chunyu Zeng

Ines Armando

Yingjin Luo

Gilbert M Eisner

Robin A Felder

Pedro A Jose

Affiliations

Soon will be listed here.

Abstract

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3), and D(4)) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.

Citing Articles

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The interplay between prolactin and cardiovascular disease.

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Synergistic Effect of Uroguanylin and D Dopamine Receptors on Sodium Excretion in Hypertension.

Zeng C, Xia T, Zheng S, Liang L, Chen Y J Am Heart Assoc. 2022; 11(6):e022827.

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