Investigation of Drug Delivery by Iontophoresis in a Surgical Wound Utilizing Microdialysis

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 2007 Dec 18

PMID 18080730

Citations 5

Authors

Heidi J Holovics

Carter R Anderson

Barry S Levine

Ho-Wah Hui

Craig E Lunte

Affiliations

Soon will be listed here.

Abstract

Purpose: This study investigated the penetration of lidocaine around and through a sutured incision following the application of iontophoretic and passive patches in the CD Hairless rat.

Materials And Methods: Concentrations in localized areas (suture, dermis, subcutaneous, and vascular) were determined using microdialysis sampling followed by analysis using liquid chromatography with UV detection.

Results: Iontophoresis significantly enhanced the dermal penetration of lidocaine. In an intact skin model, dermal concentrations were 40 times greater following iontophoretic delivery compared to passive delivery. In a sutured incision model, iontophoresis enhanced localized concentrations in the dermis, suture, and subcutaneous regions by 6-, 15-, and 20-fold, respectively. Iontophoretic delivery to a region containing a sutured incision was focused to the incision resulting in a greater increase in the suture concentration and in the subcutaneous region directly below the incision.

Conclusions: The four microdialysis probe design was successful in the determination of localized drug penetration in a sutured incision model. Iontophoresis enhanced skin penetration and allowed for site specific delivery when applied to a sutured incision.

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