Evidence for Pancreatic Beta-cell Dysfunction in Brothers of Women with Polycystic Ovary Syndrome

Overview

Journal Metabolism

Specialty Endocrinology

Date 2007 Dec 15

PMID 18078863

Citations 27

Authors

Susan Sam

Yeon-Ah Sung

Richard S Legro

Andrea Dunaif

Affiliations

Soon will be listed here.

Abstract

Hyperandrogenemia and insulin resistance are heritable traits in sisters of women with polycystic ovary syndrome (PCOS). Hyperandrogenemia also appears to be the male reproductive phenotype; however, it is less clear whether male relatives are at risk for the metabolic disorders associated with PCOS. In this study, we tested the hypothesis that brothers of women with PCOS have defects in insulin action and/or secretion. Twenty-three non-Hispanic white brothers of women with PCOS and 23 non-Hispanic white control men of comparable age matched for body mass index underwent a modified frequently sampled intravenous glucose tolerance test. Parameters of insulin sensitivity and secretion were determined using minimal-model Bergman protocol. Disposition index was significantly decreased (2540 [1080, 3172] vs 2901 [2096, 4487], P = .009) independent of a family history of diabetes mellitus, and glucose effectiveness was significantly increased (2.4 [1.9, 2.7] vs 2.0 [1.8, 2.2], P = .02) in brothers compared with control men. We conclude that brothers of women with PCOS have evidence for pancreatic beta-cell dysfunction and may be at increased risk for type 2 diabetes mellitus.

Citing Articles

Polycystic ovary syndrome.

Stener-Victorin E, Teede H, Norman R, Legro R, Goodarzi M, Dokras A Nat Rev Dis Primers. 2024; 10(1):27.

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Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome.

Risal S, Li C, Luo Q, Fornes R, Lu H, Eriksson G Cell Rep Med. 2023; 4(5):101035.

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Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance.

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Update on Animal Models of Polycystic Ovary Syndrome.

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Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk.

Torchen L, Tsai J, Jasti P, Macaya R, Sisk R, Dapas M Obesity (Silver Spring). 2019; 28(1):106-113.

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