Sex-related Time-dependent Variations in Post-stroke Survival--evidence of a Female Stroke Survival Advantage

Overview

Journal Neuroepidemiology

Specialties Neurology
Public Health

Date 2007 Dec 14

PMID 18075278

Citations 17

Authors

Tom Skyhoj Olsen

Christian Dehlendorff

Klaus Kaae Andersen

Affiliations

Soon will be listed here.

Abstract

Background: Women live longer than men, yet most studies show that gender has no influence on survival after stroke.

Methods: A registry was started in 2001, with the aim of registering all hospitalized stroke patients in Denmark, and it now holds 39,484 patients of which 48% are female. We studied the influence of gender on post-stroke mortality, from the time of admission through the subsequent years until death or censoring (mean follow-up time: 538 days). All patients underwent an evaluation including stroke severity, computed tomography and cardiovascular risk factors. Independent predictors of death were identified by means of a survival model based on 22,222 individuals with a complete data set.

Results: Females were older and had severer stroke. Interestingly, the risk of death between genders was time dependent. The female/male stroke mortality rate favoured women from the first day of stroke and remained so during the first month suggesting a female survival advantage. Throughout the second month the rate reversed in favour of men suggesting that women in that period are paying a 'toll' for their initial survival advantage. Hereafter, the rate steadily decreased, and after 4 months women continued to have the same low risk as in the first week.

Conclusions: Our study suggests a female superiority in stroke survival competence.

Citing Articles

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Hald S, Kring Sloth C, Agger M, Schelde-Olesen M, Hojholt M, Hasle M Clin Epidemiol. 2020; 12:1313-1325.

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