Vasopressin Treatment of Verapamil Toxicity in the Porcine Model

Overview

Journal J Med Toxicol

Publisher Springer

Specialty Toxicology

Date 2007 Dec 12

PMID 18072096

Citations 3

Authors

J Dave Barry

Dave Durkovich

Lee Cantrell

William Richardson

Tri Tong

Steve Offerman

Richard F Clark

David A Tanen

Saralyn Williams

Affiliations

Soon will be listed here.

Abstract

Introduction: Vasopressin is a novel vasopressor agent used for intractable hypotension. There is little published data available on its use in the poisoned patient. We performed a randomized, controlled, blinded trial in a porcine model to study the effects of vasopressin infusion on mean arterial pressure after verapamil poisoning.

Methods: Eighteen anesthetized monitored swine received a verapamil infusion of 1 mg/kg/hr until the mean arterial pressure (MAP) had decreased to 70% of baseline. At this time, a continuous infusion of either vasopressin (0.01 U/kg/min) or an equal volume of normal saline was initiated. The swine were monitored for 60 minutes after initiation of the study infusion. The primary outcome was MAP.

Results: There was no statistically significant difference between the two groups in MAP, cardiac output or systemic vascular resistance. One half (four of eight) of the animals in the vasopressin group died, compared with 20% (two of ten) of those in the saline group.

Conclusions: Vasopressin infusion decreased the survival of verapamil-poisoned swine when compared to those treated with saline alone in this experimental model.

Citing Articles

Pharmacological and mechanical management of calcium channel blocker toxicity.

Fadhlillah F, Patil S BMJ Case Rep. 2018; 2018.

PMID: 30150339 PMC: 6119390. DOI: 10.1136/bcr-2018-225324.

Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults.

St-Onge M, Anseeuw K, Cantrell F, Gilchrist I, Hantson P, Bailey B Crit Care Med. 2016; 45(3):e306-e315.

PMID: 27749343 PMC: 5312725. DOI: 10.1097/CCM.0000000000002087.

Treatment for calcium channel blocker poisoning: a systematic review.

St-Onge M, Dube P, Gosselin S, Guimont C, Godwin J, Archambault P Clin Toxicol (Phila). 2014; 52(9):926-44.

PMID: 25283255 PMC: 4245158. DOI: 10.3109/15563650.2014.965827.

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