Activation and Regulation of ATM Kinase Activity in Response to DNA Double-strand Breaks

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2007 Dec 11

PMID 18066086

Citations 292

Authors

J-H Lee

T T Paull

Affiliations

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Abstract

The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complex in this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells.

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