How Does Intracellular Ca2+ Oscillate: by Chance or by the Clock?

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2007 Dec 11

PMID 18065468

Citations 74

Authors

Alexander Skupin

Helmut Kettenmann

Ulrike Winkler

Maria Wartenberg

Heinrich Sauer

Stephen C Tovey

Colin W Taylor

Martin Falcke

Affiliations

Soon will be listed here.

Abstract

Ca2+ oscillations have been considered to obey deterministic dynamics for almost two decades. We show for four cell types that Ca2+ oscillations are instead a sequence of random spikes. The standard deviation of the interspike intervals (ISIs) of individual spike trains is similar to the average ISI; it increases approximately linearly with the average ISI; and consecutive ISIs are uncorrelated. Decreasing the effective diffusion coefficient of free Ca2+ using Ca2+ buffers increases the average ISI and the standard deviation in agreement with the idea that individual spikes are caused by random wave nucleation. Array-enhanced coherence resonance leads to regular Ca2+ oscillations with small standard deviation of ISIs.

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