Lack of Association Between Interleukin-4 Gene Polymorphisms and Autoimmune Thyroid Diseases Amongst Taiwanese Chinese

Overview

Journal Endocrine

Specialty Endocrinology

Date 2007 Dec 7

PMID 18058260

Citations 4

Authors

Rong-Hsing Chen

Chwen-Tzuei Chang

Tzu-Yuan Wang

Ching-Chu Chen

Chang-Hai Tsai

Fuu-Jen Tsai

Affiliations

Soon will be listed here.

Abstract

Graves' disease (GD) and Hashimoto's thyroiditis (HT) are both common autoimmune diseases of the thyroid gland (AITD). The IL-4 is involved in both humoral and cellular immunity. The aim of this study was to test whether the IL-4 gene could be used as a genetic marker to predict the development of AITD amongst the Chinese population of Taiwan. For this study, a normal control group of 105 healthy subjects and two experimental groups featuring individuals afflicted with either GD (104 patients) or HT (109 patients) were examined. Polymerase chain reaction (PCR) was used to analyze the variable number of tandem repeats (VNTRs) polymorphism for the IL-4 gene intron 3 and PCR-based restriction analysis using endonuclease BsmFI was undertaken for the same gene at the promoter -590 position. We found no significant difference in the frequencies of presence of genotype and allelic variants for the IL-4 gene at both the intron 3 and the promoter regions between the normal control group and each of the two patient groups. These findings suggest that the IL-4 gene polymorphisms that arise at either intron 3 or promoter -590 positions are not suitable genetic markers for AITD among Taiwanese Chinese.

Citing Articles

Association between polymorphism within interleukin related genes and Graves' disease: a meta-analysis of 22 case-control studies.

Tu Y, Fan G, Zeng T, Cai X, Kong W Oncotarget. 2017; 8(58):98993-99002.

PMID: 29228744 PMC: 5716784. DOI: 10.18632/oncotarget.20114.

Cytometric evaluation of intracellular IFN-γ and IL-4 levels in thyroid follicular cells from patients with autoimmune thyroid diseases.

Bossowski A, Harasymczuk J, Moniuszko A, Bossowska A, Hilczer M, Ratomski K Thyroid Res. 2011; 4:13.

PMID: 21943174 PMC: 3189885. DOI: 10.1186/1756-6614-4-13.

Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease.

Zhu W, Liu N, Zhao Y, Jia H, Cui B, Ning G J Endocrinol Invest. 2010; 33(10):751-5.

PMID: 20332709 DOI: 10.1007/BF03346682.

Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.

Huber A, Menconi F, Corathers S, Jacobson E, Tomer Y Endocr Rev. 2008; 29(6):697-725.

PMID: 18776148 PMC: 2583387. DOI: 10.1210/er.2008-0015.

References

Paul W . Interleukin-4: a prototypic immunoregulatory lymphokine. Blood. 1991; 77(9):1859-70. View

Mout R, Willemze R, Landegent J . Repeat polymorphisms in the interleukin-4 gene (IL4). Nucleic Acids Res. 1991; 19(13):3763. PMC: 328438. DOI: 10.1093/nar/19.13.3763. View

Walley A, Cookson W . Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet. 1996; 33(8):689-92. PMC: 1050705. DOI: 10.1136/jmg.33.8.689. View

Trenn G, Takayama H, Hu-Li J, Paul W, Sitkovsky M . B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes. J Immunol. 1988; 140(4):1101-6. View

Hunt P, Marshall S, Weetman A, Bell J, Wass J, Welsh K . Cytokine gene polymorphisms in autoimmune thyroid disease. J Clin Endocrinol Metab. 2000; 85(5):1984-8. DOI: 10.1210/jcem.85.5.6588. View

Defrance T, Vanbervliet B, Aubry J, Takebe Y, Arai N, Miyajima A . B cell growth-promoting activity of recombinant human interleukin 4. J Immunol. 1987; 139(4):1135-41. View

Chiovato L, Bassi P, Santini F, Mammoli C, Lapi P, Carayon P . Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. J Clin Endocrinol Metab. 1993; 77(6):1700-5. DOI: 10.1210/jcem.77.6.7903315. View

WOOLNER L, McConahey W, BEAHRS O . Struma lymphomatosa (Hashimoto's thyroiditis) and related thyroidal disorders. J Clin Endocrinol Metab. 1959; 19(1):53-83. DOI: 10.1210/jcem-19-1-53. View

Wu K, Peng C, Li T, Wan L, Tsai C, Lan S . Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura. Br J Haematol. 2005; 128(6):849-52. DOI: 10.1111/j.1365-2141.2005.05385.x. View

10.

Tepper R, Levinson D, Stanger B, Abbas A, Leder P . IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 1990; 62(3):457-67. DOI: 10.1016/0092-8674(90)90011-3. View

11.

Weetman A . Autoimmune thyroiditis: predisposition and pathogenesis. Clin Endocrinol (Oxf). 1992; 36(4):307-23. DOI: 10.1111/j.1365-2265.1992.tb01453.x. View

12.

Heward J, Nithiyananthan R, Allahabadia A, Gibson S, Franklyn J, Gough S . No association of an interleukin 4 gene promoter polymorphism with Graves' disease in the United Kingdom. J Clin Endocrinol Metab. 2001; 86(8):3861-3. DOI: 10.1210/jcem.86.8.7744. View

13.

Le Beau M, Lemons R, Espinosa 3rd R, Larson R, Arai N, Rowley J . Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). Blood. 1989; 73(3):647-50. View

14.

Martin A, Davies T . T cells and human autoimmune thyroid disease: emerging data show lack of need to invoke suppressor T cell problems. Thyroid. 1992; 2(3):247-61. DOI: 10.1089/thy.1992.2.247. View

15.

Larsen P, ALEXANDER N, Chopra I, Hay I, Hershman J, KAPLAN M . Revised nomenclature for tests of thyroid hormones and thyroid-related proteins in serum. Arch Pathol Lab Med. 1987; 111(12):1141-5. View

16.

Widmer M, Grabstein K . Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Nature. 1987; 326(6115):795-8. DOI: 10.1038/326795a0. View

17.

Kotani T, Aratake Y, Hirai K, Fukazawa Y, Sato H, OHTAKI S . Apoptosis in thyroid tissue from patients with Hashimoto's thyroiditis. Autoimmunity. 1995; 20(4):231-6. DOI: 10.3109/08916939508995700. View

18.

Yanagawa T, Taniyama M, Enomoto S, Gomi K, Maruyama H, Ban Y . CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid. 1998; 7(6):843-6. DOI: 10.1089/thy.1997.7.843. View

19.

Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, Hamaoka T . Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med. 1982; 155(3):914-23. PMC: 2186613. DOI: 10.1084/jem.155.3.914. View

20.

Cantagrel A, Navaux F, Nourhashemi F, Enault G, Abbal M, Constantin A . Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis. Arthritis Rheum. 1999; 42(6):1093-100. DOI: 10.1002/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P. View