Acceptor Proteins in Rat Androgenic Tissue Chromatin

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1976 Jun 1

PMID 180532

Citations 10

Authors

J F Chiu

Y H Tsai

L S Hnilica

Affiliations

Soon will be listed here.

Abstract

Fractionation of chromatin into urea-soluble chromosomal nonhistone proteins (UP), histones (HP), and DNA-associated nonhistone proteins (NP) revealed that the NP fraction from testicular and prostatic chromatin contains organ-specific acceptors for complexes of 5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and its receptor. This acceptor capacity of androgenic tissue chromatin could be transferred to chromatins from non-target tissues with the NP fraction of DNA-associated proteins. Phosphorylation of chromatin enhanced its hormone-receptor binding capacity.

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