» Articles » PMID: 18049863

Osteopontin: Regulation in Tumor Metastasis

Overview
Specialty Oncology
Date 2007 Dec 1
PMID 18049863
Citations 153
Authors
Affiliations
Soon will be listed here.
Abstract

Osteopontin is a secreted phosphoprotein that has been implicated as an important mediator of tumor metastasis and has been investigated for use as a biomarker for advanced disease and as a potential therapeutic target in the regulation of cancer metastasis. The OPN DNA sequence is highly conserved and the protein contains several important functional domains including alpha(v)beta integrin and CD44 binding sites. High levels of OPN expression correlate with tumor invasion, progression or metastasis in multiple cancer. Studies demonstrate that osteopontin mediates the molecular mechanisms which determine metastatic spread, such as prevention of apoptosis, extracellular matrix proteolysis and remodeling, cell migration, evasion of host-immune cells and neovascularization. Transcriptional regulation of OPN is complex and involves multiple pathways, including AP-1, Myc, v-Src, Runx/CBF, TGF-B/BMPs/Smad/Hox, and Wnt/ss-catenin/APC/GSK-3ss/Tcf-4. The current state of knowledge of OPN biology suggests that it is an attractive target for therapeutic modulation of metastatic disease.

Citing Articles

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.

DeSpenza Jr T, Kiziltug E, Allington G, Barson D, McGee S, OConnor D Nat Neurosci. 2025; 28(3):536-557.

PMID: 39994410 DOI: 10.1038/s41593-024-01865-3.


Osteopontin: A Key Multifaceted Regulator in Tumor Progression and Immunomodulation.

Panda V, Mishra B, Nath A, Butti R, Yadav A, Malhotra D Biomedicines. 2024; 12(7).

PMID: 39062100 PMC: 11274826. DOI: 10.3390/biomedicines12071527.


SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.

Kalnytska O, Qvist P, Kunz S, Conrad T, Willnow T, Schmidt V iScience. 2024; 27(1):108725.

PMID: 38226160 PMC: 10788290. DOI: 10.1016/j.isci.2023.108725.


Circulating sRANKL, Periostin, and Osteopontin as Biomarkers for the Assessment of Activated Osteoclastogenesis in Myeloma Related Bone Disease.

Gerov V, Gerova D, Micheva I, Nikolova M, Pasheva M, Nazifova N Cancers (Basel). 2023; 15(23).

PMID: 38067265 PMC: 10705189. DOI: 10.3390/cancers15235562.


Osteopontin: an essential regulatory protein in idiopathic pulmonary fibrosis.

Zhu X, Ji J, Han X J Mol Histol. 2023; 55(1):1-13.

PMID: 37878112 DOI: 10.1007/s10735-023-10169-y.