Alpha 2.0
Login Register
» Articles » PMID: 18047527

Maximum Likelihood Ratio Tests for Comparing the Discriminatory Ability of Biomarkers Subject to Limit of Detection

Overview
Journal Biometrics
Publisher Oxford University Press
Specialty Public Health
Date 2007 Dec 1
PMID 18047527
Citations 21
Authors
Albert Vexler
Aiyi Liu
Ekaterina Eliseeva
Enrique F Schisterman
Affiliations
Soon will be listed here.
Abstract

In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.

Citing Articles

A resample-replace lasso procedure for combining high-dimensional markers with limit of detection.

Wang J, Zhao Y, Tang L, Mueller C, Li Q J Appl Stat. 2022; 49(16):4278-4293.

PMID: 36353301 PMC: 9639487. DOI: 10.1080/02664763.2021.1977785.

Semiparametric analysis of a generalized linear model with multiple covariates subject to detection limits.

Chen L, Fine J, Bair E, Ritter V, McElrath T, Cantonwine D Stat Med. 2022; 41(24):4791-4808.

PMID: 35909228 PMC: 9588684. DOI: 10.1002/sim.9536.

A nonlinear measurement error model and its application to describing the dependency of health outcomes on dietary intake.

Curley B J Appl Stat. 2022; 49(6):1485-1518.

PMID: 35707108 PMC: 9041747. DOI: 10.1080/02664763.2020.1870671.

Estimating the AUC with a Graphical Lasso Method for High-dimensional Biomarkers with LOD.

Wang J, Zhao Y, Tang L Biostat Epidemiol. 2022; 5(2):189-206.

PMID: 35415380 PMC: 9000202. DOI: 10.1080/24709360.2021.1898731.

A family of estimators to diagnostic accuracy when candidate tests are subject to detection limits-Application to diagnosing early stage Alzheimer disease.

Xiong C, Luo J, Agboola F, Grant E, Morris J Stat Methods Med Res. 2022; 31(5):882-898.

PMID: 35044258 PMC: 9018582. DOI: 10.1177/09622802211072511.

References
1.
Lubin J, Colt J, Camann D, Davis S, Cerhan J, Severson R . Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect. 2004; 112(17):1691-6. PMC: 1253661. DOI: 10.1289/ehp.7199. View
2.
Schisterman E, Vexler A, Whitcomb B, Liu A . The limitations due to exposure detection limits for regression models. Am J Epidemiol. 2006; 163(4):374-83. PMC: 1408541. DOI: 10.1093/aje/kwj039. View
3.
Shapiro D . The interpretation of diagnostic tests. Stat Methods Med Res. 1999; 8(2):113-34. DOI: 10.1177/096228029900800203. View
4.
Reiser B, Faraggi D . Confidence intervals for the generalized ROC criterion. Biometrics. 1997; 53(2):644-52. View
5.
Perkins N, Schisterman E, Vexler A . Receiver operating characteristic curve inference from a sample with a limit of detection. Am J Epidemiol. 2006; 165(3):325-33. DOI: 10.1093/aje/kwk011. View