A Comparative Study Between Mixed-type Tumours from Human Salivary and Canine Mammary Glands

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2007 Nov 30

PMID 18045453

Citations 10

Authors

Marisa C L S Genelhu

Sergio V Cardoso

Helenice Gobbi

Geovanni D Cassali

Affiliations

Soon will be listed here.

Abstract

Background: In comparative pathology, canine mammary tumours have special interest because of their similarities with human breast cancer. Mixed tumours are uncommon lesions in the human breast, but they are found most frequently in the mammary gland of the female dogs and in the human salivary glands. The aim of the study was to compare clinical, morphological and immunohistochemical features of human salivary and canine mammary gland mixed tumours, in order to evaluate the latter as an experimental model for salivary gland tumours.

Methods: Ten examples of each mixed tumour type (human pleomorphic adenoma and carcinomas ex-pleomorphic adenomas and canine mixed tumour and metaplastic carcinoma) were evaluated. First, clinical and morphologic aspects of benign and malignant variants were compared between the species. Then, streptavidin-biotin-peroxidase immunohistochemistry was performed to detect the expression of cytokeratins, vimentin, p63 protein, estrogen receptor, beta-catenin, and E-cadherin.

Results: After standardization, similar age and site distributions were observed in human and canine tumours. Histological similarities were identified in the comparison of the benign lesions as well. Metaplastic carcinomas also resembled general aspects of carcinomas ex-pleomorphic adenomas in morphological evaluation. Additionally, immunohistochemical staining further presented similar antigenic expression between lesions.

Conclusion: There are many similar features between human salivary and canine mammary gland mixed tumours. This observation is of great relevance for those interested in the study and management of salivary gland tumours, since canine lesions may constitute useful comparative models for their investigations.

Citing Articles

Canine, Feline, and Murine Mammary Tumors as a Model for Translational Research in Breast Cancer.

Cassali G, Nakagaki K, Salvi M, Dos Reys M, Rocha M, de Campos C Vet Sci. 2025; 12(2).

PMID: 40005948 PMC: 11860833. DOI: 10.3390/vetsci12020189.

A Comparative Review of Mixed Mammary Tumors in Mammals.

Saad E, Lam J, Al-Khan A, Tayebi M, Day M, Richardson S J Mammary Gland Biol Neoplasia. 2018; 24(2):125-137.

PMID: 30488318 DOI: 10.1007/s10911-018-9422-2.

HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland.

Damasceno K, Ferreira E, Estrela-Lima A, Gamba C, Miranda F, Alves M PLoS One. 2016; 11(8):e0160419.

PMID: 27490467 PMC: 4973898. DOI: 10.1371/journal.pone.0160419.

Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.

Rakha E, Badve S, Eusebi V, Reis-Filho J, Fox S, Dabbs D Histopathology. 2015; 68(1):45-56.

PMID: 26348644 PMC: 4987288. DOI: 10.1111/his.12861.

Canine mammary mixed tumours: a review.

Cassali G, Bertagnolli A, Ferreira E, Damasceno K, Gamba C, de Campos C Vet Med Int. 2012; 2012:274608.

PMID: 23193497 PMC: 3485544. DOI: 10.1155/2012/274608.

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