» Articles » PMID: 18040063

The Human Red Blood Cell Proteome and Interactome

Overview
Specialty Biology
Date 2007 Nov 28
PMID 18040063
Citations 57
Authors
Affiliations
Soon will be listed here.
Abstract

The red blood cell or erythrocyte is easily purified, readily available, and has a relatively simple structure. Therefore, it has become a very well studied cell in terms of protein composition and function. RBC proteomic studies performed over the last five years, by several laboratories, have identified 751 proteins within the human erythrocyte. As RBCs contain few internal structures, the proteome will contain far fewer proteins than nucleated cells. In this minireview, we summarize the current knowledge of the RBC proteome, discuss alterations in this partial proteome in varied human disease states, and demonstrate how in silico studies of the RBC interactome can lead to considerable insight into disease diagnosis, severity, and drug or gene therapy response. To make these latter points we focus on what is known concerning changes in the RBC proteome in Sickle Cell Disease.

Citing Articles

Carboxyhemoglobin (COHb): Unavoidable Bystander or Protective Player?.

Carrola A, Romao C, Vieira H Antioxidants (Basel). 2023; 12(6).

PMID: 37371928 PMC: 10294805. DOI: 10.3390/antiox12061198.


The time-course linkage between hemolysis, redox, and metabolic parameters during red blood cell storage with or without uric acid and ascorbic acid supplementation.

Anastasiadi A, Stamoulis K, Papageorgiou E, Lelli V, Rinalducci S, Papassideri I Front Aging. 2023; 4:1161565.

PMID: 37025499 PMC: 10072267. DOI: 10.3389/fragi.2023.1161565.


Tubulin-mediated anatomical and functional changes caused by Ca in human erythrocytes.

Balach M, Santander V, Elisio E, Rivelli J, Muhlberger T, Campetelli A J Physiol Biochem. 2023; 79(3):511-527.

PMID: 36773113 DOI: 10.1007/s13105-023-00946-4.


The protein organization of a red blood cell.

Sae-Lee W, McCafferty C, Verbeke E, Havugimana P, Papoulas O, McWhite C Cell Rep. 2022; 40(3):111103.

PMID: 35858567 PMC: 9764456. DOI: 10.1016/j.celrep.2022.111103.


Early and Late-Phase 24 h Responses of Stored Red Blood Cells to Recipient-Mimicking Conditions.

Tzounakas V, Anastasiadi A, Karadimas D, Velentzas A, Anastasopoulou V, Papageorgiou E Front Physiol. 2022; 13:907497.

PMID: 35721567 PMC: 9198496. DOI: 10.3389/fphys.2022.907497.