ARWEN: a Program to Detect TRNA Genes in Metazoan Mitochondrial Nucleotide Sequences

Overview

Journal Bioinformatics

Publisher Oxford University Press

Specialty Biology

Date 2007 Nov 24

PMID 18033792

Citations 632

Authors

Dean Laslett

Bjorn Canback

Affiliations

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Abstract

Motivation: Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.

Results: In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100% of previously annotated genes.

Availability: An online version, software for download and test results are available at www.acgt.se/online.html

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