Thickening in the Somatosensory Cortex of Patients with Migraine

Overview

Journal Neurology

Specialty Neurology

Date 2007 Nov 21

PMID 18025393

Citations 106

Authors

Alexandre F M DaSilva

Cristina Granziera

Josh Snyder

Nouchine Hadjikhani

Affiliations

Soon will be listed here.

Abstract

Objective: To examine morphologic changes in the somatosensory cortex (SSC) of patients with migraine.

Methods: Cortical thickness of the SSC of patients with migraine was measured in vivo and compared with age- and sex-matched healthy subjects. The cohort was composed of 24 patients with migraine, subdivided into 12 patients who had migraine with aura, 12 patients who had migraine without aura, and 12 controls. Group and individual analyses were performed in the SSC and shown as average maps of significant changes in cortical thickness.

Results: Migraineurs had on average thicker SSCs than the control group. The most significant thickness changes were noticed in the caudal SSC, where the trigeminal area, including head and face, is somatotopically represented.

Conclusions: Our findings indicate the presence of interictal structural changes in the somatosensory cortex (SSC) of migraineurs. The SSC plays a crucial role in the noxious and nonnoxious somatosensory processing. Thickening in the SSC is in line with diffusional abnormalities observed in the subcortical trigeminal somatosensory pathway of the same migraine cohort in a previous study. Repetitive migraine attacks may lead to, or be the result of, neuroplastic changes in cortical and subcortical structures of the trigeminal somatosensory system.

Citing Articles

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References

Russell M, Iversen H, Olesen J . Improved description of the migraine aura by a diagnostic aura diary. Cephalalgia. 1994; 14(2):107-17. DOI: 10.1046/j.1468-2982.1994.1402107.x. View

Hagihara H, Hara M, Tsunekawa K, Nakagawa Y, Sawada M, Nakano K . Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice. Brain Res Mol Brain Res. 2005; 139(2):258-66. DOI: 10.1016/j.molbrainres.2005.05.031. View

Aurora S, Welch K, Al-Sayed F . The threshold for phosphenes is lower in migraine. Cephalalgia. 2003; 23(4):258-63. DOI: 10.1046/j.1468-2982.2003.00471.x. View

Fischl B, Sereno M, Tootell R, Dale A . High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp. 2000; 8(4):272-84. PMC: 6873338. DOI: 10.1002/(sici)1097-0193(1999)8:4<272::aid-hbm10>3.0.co;2-4. View

Waeber C, Moskowitz M . Migraine as an inflammatory disorder. Neurology. 2005; 64(10 Suppl 2):S9-15. DOI: 10.1212/wnl.64.10_suppl_2.s9. View

Liljestrom M, Le Bell Y, Anttila P, Aromaa M, Jamsa T, Metsahonkala L . Headache children with temporomandibular disorders have several types of pain and other symptoms. Cephalalgia. 2005; 25(11):1054-60. DOI: 10.1111/j.1468-2982.2005.00957.x. View

Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S . Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage. 2006; 32(1):180-94. DOI: 10.1016/j.neuroimage.2006.02.051. View

DaSilva A, Becerra L, Makris N, Strassman A, Gonzalez R, Geatrakis N . Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002; 22(18):8183-92. PMC: 6758094. View

Sessle B . Acute and chronic craniofacial pain: brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates. Crit Rev Oral Biol Med. 2000; 11(1):57-91. DOI: 10.1177/10454411000110010401. View

10.

Thompson P, Hayashi K, Sowell E, Gogtay N, Giedd J, Rapoport J . Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia. Neuroimage. 2004; 23 Suppl 1:S2-18. DOI: 10.1016/j.neuroimage.2004.07.071. View

11.

Hagen E, Svensen E, Eriksen H, Ihlebaek C, Ursin H . Comorbid subjective health complaints in low back pain. Spine (Phila Pa 1976). 2006; 31(13):1491-5. DOI: 10.1097/01.brs.0000219947.71168.08. View

12.

Kleim J, Barbay S, Cooper N, Hogg T, Reidel C, Remple M . Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol Learn Mem. 2001; 77(1):63-77. DOI: 10.1006/nlme.2000.4004. View

13.

Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A . Neuroplasticity: changes in grey matter induced by training. Nature. 2004; 427(6972):311-2. DOI: 10.1038/427311a. View

14.

Rocca M, Ceccarelli A, Falini A, Colombo B, Tortorella P, Bernasconi L . Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke. 2006; 37(7):1765-70. DOI: 10.1161/01.STR.0000226589.00599.4d. View

15.

Singh V, Chertkow H, Lerch J, Evans A, Dorr A, Kabani N . Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease. Brain. 2006; 129(Pt 11):2885-93. DOI: 10.1093/brain/awl256. View

16.

Mitsikostas D, Del Rio M . Receptor systems mediating c-fos expression within trigeminal nucleus caudalis in animal models of migraine. Brain Res Brain Res Rev. 2001; 35(1):20-35. DOI: 10.1016/s0165-0173(00)00048-5. View

17.

Burstein R, Yarnitsky D, Ransil B, Bajwa Z . An association between migraine and cutaneous allodynia. Ann Neurol. 2000; 47(5):614-24. View

18.

Sailer M, Fischl B, Salat D, Tempelmann C, Schonfeld M, Busa E . Focal thinning of the cerebral cortex in multiple sclerosis. Brain. 2003; 126(Pt 8):1734-44. DOI: 10.1093/brain/awg175. View

19.

Hadjikhani N, Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B . Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001; 98(8):4687-92. PMC: 31895. DOI: 10.1073/pnas.071582498. View

20.

DaSilva A, Granziera C, Tuch D, Snyder J, Vincent M, Hadjikhani N . Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine. Neuroreport. 2007; 18(4):301-5. PMC: 3745625. DOI: 10.1097/WNR.0b013e32801776bb. View