Iron, Hepatitis C Virus, and Hepatocellular Carcinoma: Iron Reduction Preaches the Gospel for Chronic Hepatitis C

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2007 Nov 17

PMID 18008038

Citations 8

Authors

Naoki Fujita

Yoshiyuki Takei

Affiliations

Soon will be listed here.

Citing Articles

Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis.

Chen J, Fu J, Zhao S, Zhang X, Chao Y, Pan Q Vet Sci. 2023; 10(7).

PMID: 37505861 PMC: 10384322. DOI: 10.3390/vetsci10070456.

Iron as a therapeutic target in chronic liver disease.

Kouroumalis E, Tsomidis I, Voumvouraki A World J Gastroenterol. 2023; 29(4):616-655.

PMID: 36742167 PMC: 9896614. DOI: 10.3748/wjg.v29.i4.616.

Ferroptosis in viral infection: the unexplored possibility.

Wang M, Joshua B, Jin N, Du S, Li C Acta Pharmacol Sin. 2021; 43(8):1905-1915.

PMID: 34873317 PMC: 8646346. DOI: 10.1038/s41401-021-00814-1.

Iron at the Interface of Hepatocellular Carcinoma.

Paganoni R, Lechel A, Vujic Spasic M Int J Mol Sci. 2021; 22(8).

PMID: 33921027 PMC: 8071427. DOI: 10.3390/ijms22084097.

Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry.

Wessling-Resnick M Annu Rev Nutr. 2018; 38:431-458.

PMID: 29852086 PMC: 6743070. DOI: 10.1146/annurev-nutr-082117-051749.

References

Iwata K, Iwasa M, Hara N, Matsumoto A, Kobayashi Y, Watanabe S . Iron content and consumption of health foods by patients with chronic hepatitis C. J Gastroenterol. 2006; 41(9):919-20. DOI: 10.1007/s00535-006-1860-8. View

Gong G, Waris G, Tanveer R, Siddiqui A . Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci U S A. 2001; 98(17):9599-604. PMC: 55498. DOI: 10.1073/pnas.171311298. View

Moriya K, Nakagawa K, Santa T, Shintani Y, Fujie H, Miyoshi H . Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res. 2001; 61(11):4365-70. View

Kiyosawa K, Tanaka E . Characteristics of hepatocellular carcinoma in Japan. Oncology. 2002; 62 Suppl 1:5-7. DOI: 10.1159/000048269. View

Frazer D, Anderson G . The orchestration of body iron intake: how and where do enterocytes receive their cues?. Blood Cells Mol Dis. 2003; 30(3):288-97. DOI: 10.1016/s1079-9796(03)00039-1. View

Borgna-Pignatti C, Vergine G, Lombardo T, Cappellini M, Cianciulli P, Maggio A . Hepatocellular carcinoma in the thalassaemia syndromes. Br J Haematol. 2003; 124(1):114-7. DOI: 10.1046/j.1365-2141.2003.04732.x. View

Haque S, Chandra B, Gerber M, Lok A . Iron overload in patients with chronic hepatitis C: a clinicopathologic study. Hum Pathol. 1996; 27(12):1277-81. DOI: 10.1016/s0046-8177(96)90337-8. View

Mandishona E, Macphail A, Gordeuk V, Kedda M, Paterson A, Rouault T . Dietary iron overload as a risk factor for hepatocellular carcinoma in Black Africans. Hepatology. 1998; 27(6):1563-6. DOI: 10.1002/hep.510270614. View

Ray R, Lagging L, Meyer K, Ray R . Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol. 1996; 70(7):4438-43. PMC: 190377. DOI: 10.1128/JVI.70.7.4438-4443.1996. View

10.

Hayashi H, TAKIKAWA T, Nishimura N, Yano M, Isomura T, Sakamoto N . Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. Am J Gastroenterol. 1994; 89(7):986-8. View

11.

Okanoue T, Makiyama A, Nakayama M, Sumida Y, Mitsuyoshi H, Nakajima T . A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase. J Hepatol. 2005; 43(4):599-605. DOI: 10.1016/j.jhep.2005.04.008. View

12.

Horiike S, Kawanishi S, Kaito M, Ma N, Tanaka H, Fujita N . Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C. J Hepatol. 2005; 43(3):403-10. DOI: 10.1016/j.jhep.2005.03.026. View

13.

Bonkovsky H . Therapy of hepatitis C: other options. Hepatology. 1997; 26(3 Suppl 1):143S-151S. DOI: 10.1002/hep.510260725. View

14.

. Chlorinated drinking-water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds. International Agency for Research on Cancer (IARC) Working Group, Lyon, 12-19 June 1990. IARC Monogr Eval Carcinog Risks Hum. 1991; 52:1-544. PMC: 7681469. View

15.

Fujita N, Sugimoto R, Urawa N, Araki J, Mifuji R, Yamamoto M . Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. J Gastroenterol Hepatol. 2007; 22(11):1886-93. DOI: 10.1111/j.1440-1746.2006.04759.x. View

16.

Sartori M, Andorno S, Rigamonti C, Grossini E, Nicosia G, Boldorini R . Chronic hepatitis C is mild in menstruating women. J Gastroenterol Hepatol. 2001; 15(12):1411-7. DOI: 10.1046/j.1440-1746.2000.02368.x. View

17.

Iwasa M, Kaito M, Ikoma J, Kobayashi Y, Tanaka Y, Higuchi K . Dietary iron restriction improves aminotransferase levels in chronic hepatitis C patients. Hepatogastroenterology. 2002; 49(44):529-31. View

18.

de Maria N, Colantoni A, Fagiuoli S, Liu G, Rogers B, Farinati F . Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radic Biol Med. 1996; 21(3):291-5. DOI: 10.1016/0891-5849(96)00044-5. View

19.

Sakamuro D, Furukawa T, Takegami T . Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol. 1995; 69(6):3893-6. PMC: 189112. DOI: 10.1128/JVI.69.6.3893-3896.1995. View

20.

Hentze M, Muckenthaler M, Andrews N . Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004; 117(3):285-97. DOI: 10.1016/s0092-8674(04)00343-5. View