Home Indoor Pollutant Exposures Among Inner-city Children with and Without Asthma

Overview

Journal Environ Health Perspect

Date 2007 Nov 17

PMID 18008001

Citations 40

Authors

Gregory B Diette

Nadia N Hansel

Timothy J Buckley

Jean Curtin-Brosnan

Peyton A Eggleston

Elizabeth C Matsui

Meredith C McCormack

DAnn L Williams

Patrick N Breysse

Affiliations

Soon will be listed here.

Abstract

Background: Evidence for environmental causes of asthma is limited, especially among African Americans. To look for systematic differences in early life domestic exposures between inner-city preschool children with and without asthma, we performed a study of home indoor air pollutants and allergens.

Methods: Children 2-6 years of age were enrolled in a cohort study in East Baltimore, Maryland. From the child's bedroom, air was monitored for 3 days for particulate matter <or= 2.5 and <or= 10 microm in aerodynamic diameter (PM(2.5), PM(10)), nitrogen dioxide, and ozone. Median baseline values were compared for children with (n = 150) and without (n = 150) asthma. Housing characteristics related to indoor air pollution were assessed by caregiver report and home inspection. In addition, indoor allergen levels were measured in settled dust.

Results: Children were 58% male, 91% African American, and 88% with public health insurance. Housing characteristics related to pollutant exposure and bedroom air pollutant concentrations did not differ significantly between asthmatic and control subjects [median: PM(2.5), 28.7 vs. 28.5 microg/m(3); PM(10), 43.6 vs. 41.4 microg/m(3); NO(2), 21.6 vs. 20.9 ppb; O(3), 1.4 vs. 1.8 ppb; all p > 0.05]. Settled dust allergen levels (cat, dust mite, cockroach, dog, and mouse) were also similar in bedrooms of asthmatic and control children.

Conclusions: Exposures to common home indoor pollutants and allergens are similar for inner-city preschool children with and without asthma. Although these exposures may exacerbate existing asthma, this study does not support a causative role of these factors for risk of developing childhood asthma.

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References

Butland B, Strachan D, Anderson H . The home environment and asthma symptoms in childhood: two population based case-control studies 13 years apart. Thorax. 1997; 52(7):618-24. PMC: 1758604. DOI: 10.1136/thx.52.7.618. View

Tavernier G, Fletcher G, Gee I, Watson A, Blacklock G, Francis H . IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children. J Allergy Clin Immunol. 2006; 117(3):656-62. DOI: 10.1016/j.jaci.2005.12.1311. View

Zanobetti A, Schwartz J, Gold D . Are there sensitive subgroups for the effects of airborne particles?. Environ Health Perspect. 2000; 108(9):841-5. PMC: 2556924. DOI: 10.1289/ehp.00108841. View

Mitchell H, Senturia Y, Gergen P, Baker D, Joseph C, Wedner H . Design and methods of the National Cooperative Inner-City Asthma Study. Pediatr Pulmonol. 1997; 24(4):237-52. DOI: 10.1002/(sici)1099-0496(199710)24:4<237::aid-ppul3>3.0.co;2-h. View

Liu L, Slaughter J, Larson T . Comparison of light scattering devices and impactors for particulate measurements in indoor, outdoor, and personal environments. Environ Sci Technol. 2002; 36(13):2977-86. DOI: 10.1021/es0112644. View

Pilotto L, Douglas R, Attewell R, Wilson S . Respiratory effects associated with indoor nitrogen dioxide exposure in children. Int J Epidemiol. 1997; 26(4):788-96. DOI: 10.1093/ije/26.4.788. View

Gold D . Environmental tobacco smoke, indoor allergens, and childhood asthma. Environ Health Perspect. 2000; 108 Suppl 4:643-51. PMC: 1637671. DOI: 10.1289/ehp.00108s4643. View

Wallace L, Duan N, Ziegenfus R . Can long-term exposure distributions be predicted from short-term measurements?. Risk Anal. 1994; 14(1):75-85. DOI: 10.1111/j.1539-6924.1994.tb00029.x. View

Rios J, Boechat J, SantAnna C, Franca A . Atmospheric pollution and the prevalence of asthma: study among schoolchildren of 2 areas in Rio de Janeiro, Brazil. Ann Allergy Asthma Immunol. 2004; 92(6):629-34. DOI: 10.1016/S1081-1206(10)61428-7. View

10.

Chapman M, Aalberse R, Brown M, Platts-Mills T . Monoclonal antibodies to the major feline allergen Fel d I. II. Single step affinity purification of Fel d I, N-terminal sequence analysis, and development of a sensitive two-site immunoassay to assess Fel d I exposure. J Immunol. 1988; 140(3):812-8. View

11.

Koppelman G . Gene by environment interaction in asthma. Curr Allergy Asthma Rep. 2006; 6(2):103-11. DOI: 10.1007/s11882-006-0047-y. View

12.

Laitinen T, Rasanen M, Kaprio J, Koskenvuo M, Laitinen L . Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am J Respir Crit Care Med. 1998; 157(4 Pt 1):1073-8. DOI: 10.1164/ajrccm.157.4.9704041. View

13.

Pollart S, Smith T, Morris E, Gelber L, Platts-Mills T, Chapman M . Environmental exposure to cockroach allergens: analysis with monoclonal antibody-based enzyme immunoassays. J Allergy Clin Immunol. 1991; 87(2):505-10. DOI: 10.1016/0091-6749(91)90009-d. View

14.

Eggleston P, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M . Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998; 102(4 Pt 1):563-70. DOI: 10.1016/s0091-6749(98)70272-6. View

15.

Long C, Suh H, Kobzik L, Catalano P, Ning Y, Koutrakis P . A pilot investigation of the relative toxicity of indoor and outdoor fine particles: in vitro effects of endotoxin and other particulate properties. Environ Health Perspect. 2001; 109(10):1019-26. PMC: 1242078. DOI: 10.1289/ehp.011091019. View

16.

Baker D, Henderson J . Differences between infants and adults in the social aetiology of wheeze. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. J Epidemiol Community Health. 2000; 53(10):636-42. PMC: 1756779. DOI: 10.1136/jech.53.10.636. View

17.

McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F . Traffic, susceptibility, and childhood asthma. Environ Health Perspect. 2006; 114(5):766-72. PMC: 1459934. DOI: 10.1289/ehp.8594. View

18.

Rea A, Zufall M, Williams R, Sheldon L, Howard-Reed C . The influence of human activity patterns on personal PM exposure: a comparative analysis of filter-based and continuous particle measurements. J Air Waste Manag Assoc. 2001; 51(9):1271-9. DOI: 10.1080/10473289.2001.10464351. View

19.

Bruce N, Perez-Padilla R, Albalak R . Indoor air pollution in developing countries: a major environmental and public health challenge. Bull World Health Organ. 2000; 78(9):1078-92. PMC: 2560841. View

20.

Long C, Suh H, Koutrakis P . Characterization of indoor particle sources using continuous mass and size monitors. J Air Waste Manag Assoc. 2000; 50(7):1236-50. DOI: 10.1080/10473289.2000.10464154. View