» Articles » PMID: 18005779

The Metastatic Lymph Node Ratio Predicts Survival in Colon Cancer

Overview
Journal Am J Surg
Specialty General Surgery
Date 2007 Nov 17
PMID 18005779
Citations 49
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Lymph node metastases are the most important predictor of survival in non-stage IV colon cancer. Recent studies of gastric cancer have shown a prognostic significance of a lymph node ratio (number of positive nodes divided by total number harvested). Our goal was to determine whether a lymph node ratio (LNR) would predict disease-free survival (DFS) and overall survival (OS) in a tertiary care Veterans Affairs medical center.

Methods: A retrospective review of a prospectively collected database of colon cancer patients was performed to determine the effect of LNR on DFS and OS. A cohort of 232 patients with non-stage IV colon cancer was eligible for analysis. Survival curves were constructed using the Kaplan-Meier method.

Results: For all patients, a LNR of .08 was identified as a breakpoint for predicting OS and DFS. Specific analysis of stage III patients revealed that a LNR of .18 was predictive of DFS.

Conclusions: This study showed the prognostic significance of ratio-based staging for colon cancer and may aid in future staging systems.

Citing Articles

The effect of lymph node ratio on the surgical outcomes in patients with colorectal cancer.

Hai Z, Peng D, Li Z, Liu F, Liu X, Wang C Sci Rep. 2024; 14(1):17689.

PMID: 39085386 PMC: 11291744. DOI: 10.1038/s41598-024-68576-4.


Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study.

Nguyen M, Dang C, Song Nguyen T, Pham N, Le D, Pham M SAGE Open Med. 2024; 12:20503121241233238.

PMID: 38456163 PMC: 10919137. DOI: 10.1177/20503121241233238.


Accuracy of papillary thyroid cancer prognostic nomograms: a systematic review.

Garo M, Deandreis D, Campenni A, Vrachimis A, Petranovic Ovcaricek P, Giovanella L Endocr Connect. 2023; 12(4).

PMID: 36662681 PMC: 10083677. DOI: 10.1530/EC-22-0457.


Anatomy of Subpancreatic Transverse Colon Vessel and Its Clinical Significance: An Observational Study.

Liao J, Qin H, Wei L, Huang Z, Meng L, Wang W Front Surg. 2022; 9:938223.

PMID: 35846971 PMC: 9283793. DOI: 10.3389/fsurg.2022.938223.


Nomograms for Differentiated Thyroid Carcinoma Patients Based on the Eighth AJCC Staging and Competing Risks Model.

Li C, Xu F, Huang Q, Han D, Zheng S, Wu W JNCI Cancer Spectr. 2021; 5(3).

PMID: 34159295 PMC: 8211639. DOI: 10.1093/jncics/pkab038.