Use of Tigecycline for the Treatment of Prolonged Bacteremia Due to a Multiresistant VIM-1 and SHV-12 Beta--lactamase-producing Klebsiella Pneumoniae Epidemic Clone

Overview

Journal Diagn Microbiol Infect Dis

Specialties Infectious Diseases
Microbiology
Pathology

Date 2007 Nov 13

PMID 17996417

Citations 18

Authors

Javier Cobo

Maria-Isabel Morosini

Vicente Pintado

Marta Tato

Noemi Samaranch

Fernando Baquero

Rafael Canton

Affiliations

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Abstract

We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-beta-lactamase (VIM-1) and an extended-spectrum beta-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone.

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