Nonuniform Size Distribution of Nascent Globin Peptides, Evidence for Pause Localization Sites, and a Contranslational Protein-folding Model

Overview

Journal J Protein Chem

Specialties Biochemistry
Chemistry

Date 1991 Oct 1

PMID 1799404

Citations 13

Authors

I A Krasheninnikov

A A Komar

I A Adzhubei

Affiliations

Soon will be listed here.

Abstract

Examination of nascent globin peptides accumulating in vitro during globin synthesis in rabbit reticulocyte lysates was carried out. A view was supported that nonrandom distribution of codons with different usage frequencies in mRNA may determine the messenger's translation kinetics. Regions of reduced translation of alpha- and beta-globin polypeptide chains were localized, and the cotranslational protein-folding model suggested previously was substantiated. An active conjunction of synthesis and folding of proteins was proposed as one of the main destinations of a translation nonuniformity.

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