Concise Review: MicroRNA Expression in Multipotent Mesenchymal Stromal Cells

Overview

Journal Stem Cells

Publisher Oxford University Press

Specialties Cell Biology
Reproductive Medicine

Date 2007 Nov 10

PMID 17991914

Citations 58

Authors

Uma Lakshmipathy

Ronald P Hart

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells, or multipotent mesenchymal stromal cells (MSC), isolated from various adult tissue sources have the capacities to self-renew and to differentiate into multiple lineages. Both of these processes are tightly regulated by genetic and epigenetic mechanisms. Emerging evidence indicates that the class of single-stranded noncoding RNAs known as microRNAs also plays a critical role in this process. First described in nematodes and plants, microRNAs have been shown to modulate major regulatory mechanisms in eukaryotic cells involved in a broad array of cellular functions. Studies with various types of embryonic as well as adult stem cells indicate an intricate network of microRNAs regulating key transcription factors and other genes, which in turn determine cell fate. In addition, expression of unique microRNAs in specific cell types serves as a useful diagnostic marker to define a particular cell type. MicroRNAs are also found to be regulated by extracellular signaling pathways that are important for differentiation into specific tissues, suggesting that they play a role in specifying tissue identity. In this review, we describe the importance of microRNAs in stem cells, focusing on our current understanding of microRNAs in MSC and their derivatives.

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References

Zeng Y, Cullen B . Sequence requirements for micro RNA processing and function in human cells. RNA. 2003; 9(1):112-23. PMC: 1370375. DOI: 10.1261/rna.2780503. View

Harfe B . MicroRNAs in vertebrate development. Curr Opin Genet Dev. 2005; 15(4):410-5. DOI: 10.1016/j.gde.2005.06.012. View

Cimmino A, Calin G, Fabbri M, Iorio M, Ferracin M, Shimizu M . miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005; 102(39):13944-9. PMC: 1236577. DOI: 10.1073/pnas.0506654102. View

Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-73. DOI: 10.1038/nature03315. View

Sempere L, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V . Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004; 5(3):R13. PMC: 395763. DOI: 10.1186/gb-2004-5-3-r13. View

Nakamoto M, Jin P, ODonnell W, Warren S . Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005; 14(24):3813-21. DOI: 10.1093/hmg/ddi397. View

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R . DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007; 39(3):380-5. PMC: 3008549. DOI: 10.1038/ng1969. View

Tuddenham L, Wheeler G, Ntounia-Fousara S, Waters J, Hajihosseini M, Clark I . The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett. 2006; 580(17):4214-7. DOI: 10.1016/j.febslet.2006.06.080. View

Chen X, Splinter P, OHara S, LaRusso N . A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem. 2007; 282(39):28929-28938. PMC: 2194650. DOI: 10.1074/jbc.M702633200. View

10.

Lim L, Lau N, Weinstein E, Abdelhakim A, Yekta S, Rhoades M . The microRNAs of Caenorhabditis elegans. Genes Dev. 2003; 17(8):991-1008. PMC: 196042. DOI: 10.1101/gad.1074403. View

11.

Zhou B, Wang S, Mayr C, Bartel D, Lodish H . miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007; 104(17):7080-5. PMC: 1855395. DOI: 10.1073/pnas.0702409104. View

12.

Lawrie C . MicroRNAs and haematology: small molecules, big function. Br J Haematol. 2007; 137(6):503-12. DOI: 10.1111/j.1365-2141.2007.06611.x. View

13.

Phinney D . Building a consensus regarding the nature and origin of mesenchymal stem cells. J Cell Biochem Suppl. 2002; 38:7-12. DOI: 10.1002/jcb.10084. View

14.

Calin G, Liu C, Sevignani C, Ferracin M, Felli N, Dumitru C . MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A. 2004; 101(32):11755-60. PMC: 511048. DOI: 10.1073/pnas.0404432101. View

15.

Lu C, Tej S, Luo S, Haudenschild C, Meyers B, Green P . Elucidation of the small RNA component of the transcriptome. Science. 2005; 309(5740):1567-9. DOI: 10.1126/science.1114112. View

16.

Couturier J, Root-Bernstein R . HIV may produce inhibitory microRNAs (miRNAs) that block production of CD28, CD4 and some interleukins. J Theor Biol. 2005; 235(2):169-84. DOI: 10.1016/j.jtbi.2005.01.001. View

17.

Cavanaugh J . Role of extracellular signal regulated kinase 5 in neuronal survival. Eur J Biochem. 2004; 271(11):2056-9. DOI: 10.1111/j.1432-1033.2004.04131.x. View

18.

John B, Enright A, Aravin A, Tuschl T, Sander C, Marks D . Human MicroRNA targets. PLoS Biol. 2004; 2(11):e363. PMC: 521178. DOI: 10.1371/journal.pbio.0020363. View

19.

Chunmeng S, Tianmin C . Skin: a promising reservoir for adult stem cell populations. Med Hypotheses. 2004; 62(5):683-8. DOI: 10.1016/j.mehy.2003.12.022. View

20.

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002; 12(9):735-9. DOI: 10.1016/s0960-9822(02)00809-6. View