Gliomatosis Cerebri: Bioptical Approach and Neuropathological Verification

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 1991 Jan 1

PMID 1799156

Citations 10

Authors

R SCHOBER

J K Mai

B Volk

W WECHSLER

Affiliations

Soon will be listed here.

Abstract

Gliomatosis cerebri is rarely encountered and its intra vitam diagnosis has remained difficult. We present biopsy and autopsy findings in three cases that are representative of diffuse glioma, gliomatosis cerebri and diffuse glioblastosis, a modification of the subclassification proposed by Zülch31. Stereotactic biopsy in conjunction with nuclear magnetic resonance tomography (MRT) is recommended as the diagnostic procedure in suspected cases. Immunohistochemical examination with a panel of neuroectodermal markers is helpful in the differential diagnosis but has to take into account that reactive astrocytes may be closely intermingled with the neoplastic glial cells.

Citing Articles

Presentation patterns and outcome of gliomatosis cerebri.

Rajz G, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen Z Oncol Lett. 2012; 3(1):209-213.

PMID: 22740882 PMC: 3362440. DOI: 10.3892/ol.2011.445.

Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases.

Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T Neurosurg Rev. 2011; 34(2):197-208.

PMID: 21301914 DOI: 10.1007/s10143-010-0306-1.

Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri.

Braeuninger S, Schneider-Stock R, Kirches E, Powers J, Korones D, Mawrin C J Neurooncol. 2006; 82(1):23-7.

PMID: 16955219 DOI: 10.1007/s11060-006-9245-7.

Gliomatosis cerebri in children. Case report and clinical considerations.

Caroli E, Orlando E, Ferrante L Childs Nerv Syst. 2005; 21(11):1000-3.

PMID: 16240166 DOI: 10.1007/s00381-004-1076-2.

Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature.

Taillibert S, Chodkiewicz C, Laigle-Donadey F, Napolitano M, Cartalat-Carel S, Sanson M J Neurooncol. 2005; 76(2):201-5.

PMID: 16200347 DOI: 10.1007/s11060-005-5263-0.

References

Delisle M, Andrieu P, Geraud G, BOUISSOU H . [Cerebral gliomatosis. An anatomoclinical case]. Ann Pathol. 1989; 9(3):214-8. View

Ostertag C, Volk B, Shibata T, Burger P, Kleihues P . The monoclonal antibody Ki-67 as a marker for proliferating cells in stereotactic biopsies of brain tumours. Acta Neurochir (Wien). 1987; 89(3-4):117-21. DOI: 10.1007/BF01560376. View

Schmidbauer M, Muller C, Podreka I, Mamoli B, Sluga E, Deecke L . Diffuse cerebrospinal gliomatosis presenting as motor neuron disease for two years. J Neurol Neurosurg Psychiatry. 1989; 52(2):275-8. PMC: 1032521. DOI: 10.1136/jnnp.52.2.275. View

Ng H . Diffuse gliomatosis of the central nervous system with histological features of microgliomatosis. Clin Neuropathol. 1988; 7(5):266-70. View

Szymas J, Reifenberger G, WECHSLER W . Leu-M1 immunoreactivity in the human brain. Discrimination between different tumors and between neoplastic and brain tissue. Naturwissenschaften. 1987; 74(4):188-90. DOI: 10.1007/BF00372924. View

Reifenberger G, Szymas J, WECHSLER W . Differential expression of glial- and neuronal-associated antigens in human tumors of the central and peripheral nervous system. Acta Neuropathol. 1987; 74(2):105-23. DOI: 10.1007/BF00692841. View

FINKEMEYER H, TZONOS T . [Clinical diagnosis of diffuse gliomatosis]. Acta Neurochir (Wien). 1965; 13(1):86-112. DOI: 10.1007/BF02074647. View

Romero F, Ortega A, Titus F, Ibarra B, Navarro C, Rovira M . Gliomatosis cerebri with formation of a glioblastoma multiform. Study and follow-up by magnetic resonance and computed tomography. J Comput Tomogr. 1988; 12(4):253-7. DOI: 10.1016/0149-936x(88)90079-3. View

DUNN Jr J, KERNOHAN J . Gliomatosis cerebri. AMA Arch Pathol. 1957; 64(1):82-91. View

10.

KAHLE W . [Problems of diffuse glioblastosis]. Dtsch Z Nervenheilkd. 1957; 176(4):469-99. View

11.

Hayek J, Valavanis A . Computed tomography of gliomatosis cerebri. Comput Radiol. 1982; 6(2):93-8. DOI: 10.1016/0730-4862(82)90151-2. View

12.

Couch J, Weiss S . Gliomatosis cerebri. Report of four cases and review of the literature. Neurology. 1974; 24(6):504-11. DOI: 10.1212/wnl.24.6.504. View

13.

Kawano N, Miyasaka Y, Yada K, Atari H, Sasaki K . Diffuse cerebrospinal gliomatosis. Case report. J Neurosurg. 1978; 49(2):303-7. DOI: 10.3171/jns.1978.49.2.0303. View

14.

Artigas J, Cervos-Navarro J, Iglesias J, Ebhardt G . Gliomatosis cerebri: clinical and histological findings. Clin Neuropathol. 1985; 4(4):135-48. View

15.

Cervos-Navarro J, Artigas J, Aruffo C, Iglesias J . The fine structure of gliomatosis cerebri. Virchows Arch A Pathol Anat Histopathol. 1987; 411(1):93-8. DOI: 10.1007/BF00734520. View

16.

Spector R, Smith J, PARKER Jr J . Cecocentral scotomas in gliomatosis cerebri. J Clin Neuroophthalmol. 1984; 4(4):229-38. View

17.

Neuhold A, Brainin M, Jellinger K . [Diffuse cerebral gliomatosis. Clinical, nuclear magnetic resonance tomography and pathologic findings]. Nervenarzt. 1989; 60(7):437-40. View

18.

Seitz D, KALM H . Diffuse Glioblastosis. Dtsch Z Nervenheilkd. 1957; 175(5):528-46. View

19.

WILSON N, Symon L, Lantos P . Gliomatosis cerebri: report of a case presenting as a focal cerebral mass. J Neurol. 1987; 234(6):445-7. DOI: 10.1007/BF00314097. View

20.

Balakrishnan V, Hornabrook R, Alexander W . Gliomatosis cerebri--report of a case. Pathology. 1985; 17(1):123-6. DOI: 10.3109/00313028509063740. View