ABCG Transporters: Structure, Substrate Specificities and Physiological Roles : a Brief Overview

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 2007 Nov 9

PMID 17990087

Citations 29

Authors

Saroj Velamakanni

Shen L Wei

Tavan Janvilisri

Hendrik W van Veen

Affiliations

Soon will be listed here.

Abstract

The ATP-binding cassette (ABC) transporter superfamily is one of the largest protein families with representatives in all kingdoms of life. Members of this superfamily are involved in a wide variety of transport processes with substrates ranging from small ions to relatively large polypeptides and polysaccharides. The G subfamily of ABC transporters consists of half-transporters, which oligomerise to form the functional transporter. While ABCG1, ABCG4 and ABCG5/8 are involved in the ATP-dependent translocation of steroids and, possibly, other lipids, ABCG2 (also termed the breast cancer resistance protein) has been identified as a multidrug transporter that confers resistance on tumor cells. Evidence will be summarized suggesting that ABCG2 can also mediate the binding/transport of non-drug substrates, including free and conjugated steroids. The characterization of the substrate specificities of ABCG proteins at a molecular level might provide further clues about their potential physiological role(s), and create new opportunities for the modulation of their activities in relation to human disease.

Citing Articles

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Xin J, Zhou Y, Qiu Y, Geng H, Wang Y, Song Y Plant Commun. 2023; 5(1):100776.

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Insights into the involvement of long non-coding RNAs in doxorubicin resistance of cancer.

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The putative ABCG transporter from grapevine () is strongly expressed in the seed coat of developing seeds and may participate in suberin biosynthesis.

Wang L, Yao W, Zhang X, Tang Y, van Nocker S, Wang Y Physiol Mol Biol Plants. 2023; 29(1):23-34.

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An Atypical ABC Transporter Is Involved in Antifungal Resistance and Host Interactions in the Pathogenic Fungus Cryptococcus neoformans.

Winski C, Qian Y, Mobashery S, Santiago-Tirado F mBio. 2022; 13(4):e0153922.

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