Murine Gammaherpesvirus 68 Genes Both Induce and Suppress Lymphoproliferative Disease

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2007 Nov 6

PMID 17977975

Citations 20

Authors

Vera L Tarakanova

Friederike Kreisel

Douglas W White

Herbert W Virgin 4th

Affiliations

Soon will be listed here.

Abstract

Gammaherpesvirus infection is associated with an increased incidence of lymphoproliferative disease in immunocompromised hosts. Murine gammaherpesvirus 68 (gammaHV68) infection of BALB beta(2)-microglobulin-deficient (BALB beta(2)m(-/-)) mice provides an animal model for analysis of the mechanisms responsible for the induction of a lymphoproliferative disease, atypical lymphoid hyperplasia (ALH), that is pathologically similar to posttransplant lymphoproliferative disease associated with Epstein-Barr virus infection. Here we report that the gammaHV68 v-cyclin and v-bcl-2 genes are required for the efficient induction of gammaHV68-associated ALH in BALB beta(2)m(-/-) mice, while the v-GPCR gene is dispensable for ALH induction. In contrast to these findings, deletion of the viral M1 gene enhanced ALH. Thus, gammaHV68 genes can either inhibit or enhance the induction of lymphoproliferative disease in immunocompromised mice.

Citing Articles

Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections.

Gaglia M Virol J. 2021; 18(1):218.

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Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68.

Wang Y, Tibbetts S, Krug L Annu Rev Virol. 2021; 8(1):349-371.

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Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.

Stoltz K, Jondle C, Pulakanti K, Sylvester P, Urrutia R, Rao S Virology. 2018; 526:52-60.

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Host Tumor Suppressor p18 Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.

Niemeyer B, Oko L, Medina E, Oldenburg D, White D, Cool C J Virol. 2018; 92(6).

PMID: 29298882 PMC: 5827403. DOI: 10.1128/JVI.01604-17.

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host.

Cieniewicz B, Santana A, Minkah N, Krug L Front Microbiol. 2016; 7:1202.

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