Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2007 Nov 1

PMID 17971752

Citations 4

Authors

George A Kraus

Jaehoon Bae

Lankun Wu

Eve Wurtele

Affiliations

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Abstract

The synthesis of the alkamides 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (1) and 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (5) was accomplished by organometallic coupling followed by introduction of the doubly unsaturated amide moiety. The distribution of these two amides in accessions of the nine species of Echinacea was determined.

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