Uterine Development in Turner Syndrome

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2007 Oct 27

PMID 17961700

Citations 17

Authors

Vladimir K Bakalov

Thomas Shawker

Irene Ceniceros

Carolyn A Bondy

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate uterine development of women with Turner syndrome (TS) receiving conventional medical care.

Study Design: In a cross-sectional study we used ultrasonography for uterine evaluation in 86 women with TS 18 to 45 years of age participating in an intramural NIH study, and who had abnormal karyotypes in >70% of white blood cells. Outcomes were uterine dimensions and shape. Information on hormone treatment was obtained by personal interview.

Results: Twenty-five percent had a mature in size and shape uterus, and 31% had an immature uterus, with the remainder in a transitional category. Twenty percent of all participants were not taking hormone replacement therapy (HRT) in the preceding year. The majority on treatment were taking conjugated estrogens (CE) or oral contraceptives (OC). Factors associated with uterine maturity were history of spontaneous puberty and duration and type of HRT, with estradiol-based treatment being the most effective. The age at starting HRT was not a critical factor.

Conclusions: Women with TS may develop a normal uterus even at a late start of HRT given adequate duration of treatment and regardless of karyotype.

Citing Articles

Exploring the interplay of karyotype, hormones, sexuality, and body image perception in individuals with Turner syndrome.

Tarantino C, Vincenzi L, Angelini F, Tomaselli A, Carlomagno F, Rosato E J Endocrinol Invest. 2025; .

PMID: 39946049 DOI: 10.1007/s40618-024-02521-0.

Turner Syndrome where are we?.

Khan N, Farooqui A, Ishrat R Orphanet J Rare Dis. 2024; 19(1):314.

PMID: 39198906 PMC: 11351000. DOI: 10.1186/s13023-024-03337-0.

Clinical practice guidelines for the care of girls and women with Turner syndrome.

Gravholt C, Andersen N, Christin-Maitre S, Davis S, Duijnhouwer A, Gawlik A Eur J Endocrinol. 2024; 190(6):G53-G151.

PMID: 38748847 PMC: 11759048. DOI: 10.1093/ejendo/lvae050.

Reproductive health in Turner's syndrome: from puberty to pregnancy.

Porcu E, Cipriani L, Damiano G Front Endocrinol (Lausanne). 2023; 14:1269009.

PMID: 38116311 PMC: 10728473. DOI: 10.3389/fendo.2023.1269009.

Normalization of puberty and adult height in girls with Turner syndrome: results of the Swedish Growth Hormone trials initiating transition into adulthood.

Kristrom B, Ankarberg-Lindgren C, Barrenas M, Nilsson K, Albertsson-Wikland K Front Endocrinol (Lausanne). 2023; 14:1197897.

PMID: 37529614 PMC: 10389045. DOI: 10.3389/fendo.2023.1197897.

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