Solution NMR of Membrane Proteins in Bilayer Mimics: Small is Beautiful, but Sometimes Bigger is Better

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2007 Oct 27

PMID 17961504

Citations 45

Authors

Sebastien F Poget

Mark E Girvin

Affiliations

Soon will be listed here.

Abstract

Considerable progress has been made recently on solution NMR studies of multi-transmembrane helix membrane protein systems of increasing size. Careful correlation of structure with function has validated the physiological relevance of these studies in detergent micelles. However, larger micelle and bicelle systems are sometimes required to stabilize the active forms of dynamic membrane proteins, such as the bacterial small multidrug resistance transporters. Even in these systems with aggregate molecular weights well over 100 kDa, solution NMR structural studies are feasible-but challenging.

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