B-cells and Humoral Immunity in Multiple Sclerosis. Implications for Therapy
Overview
Affiliations
B-cells and humoral immunity have been implicated in the pathogenesis of multiple sclerosis. The most common pattern of demyelinating pathology in multiple sclerosis is associated with the deposition of antibodies and the activation of complement, as well as T-cells and macrophages. Plasmapheresis has been found to be an efficient therapeutic approach in patients with this type of pathological lesion. Recent data have indicated that autoantibodies and complement C5b-9 may be involved in lesion formation and might also be beneficial for lesion repair. Thus, the role played by B-cells and humoral immunity is rather complex, and new strategies for targeting B-cell responses are continuing to emerge.
Soluble Antigen Arrays for Selective Desensitization of Insulin-Reactive B Cells.
Leon M, Wemlinger S, Larson N, Ruffalo J, Sestak J, Middaugh C Mol Pharm. 2019; 16(4):1563-1572.
PMID: 30681867 PMC: 7446942. DOI: 10.1021/acs.molpharmaceut.8b01250.
Hartwell B, Pickens C, Leon M, Berkland C Biomacromolecules. 2017; 18(6):1893-1907.
PMID: 28474886 PMC: 7388272. DOI: 10.1021/acs.biomac.7b00335.
Bellavista E, Santoro A, Galimberti D, Comi C, Luciani F, Mishto M Autoimmune Dis. 2014; 2014:739705.
PMID: 24523959 PMC: 3910067. DOI: 10.1155/2014/739705.
Crespo O, Kang S, Daneman R, Lindstrom T, Ho P, Sobel R J Clin Immunol. 2011; 31(6):1010-20.
PMID: 21847523 PMC: 3225802. DOI: 10.1007/s10875-011-9579-6.
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.
Laursen N, Gordon N, Hermans S, Lorenz N, Jackson N, Wines B Proc Natl Acad Sci U S A. 2010; 107(8):3681-6.
PMID: 20133685 PMC: 2840425. DOI: 10.1073/pnas.0910565107.