Necdin Mediates Skeletal Muscle Regeneration by Promoting Myoblast Survival and Differentiation

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2007 Oct 24

PMID 17954612

Citations 30

Authors

Daniela Deponti

Stephanie Francois

Silvia Baesso

Clara Sciorati

Anna Innocenzi

Vania Broccoli

Francoise Muscatelli

Raffaella Meneveri

Emilio Clementi

Giulio Cossu

Silvia Brunelli

Affiliations

Soon will be listed here.

Abstract

Regeneration of muscle fibers that are lost during pathological muscle degeneration or after injuries is sustained by the production of new myofibers. An important cell type involved in muscle regeneration is the satellite cell. Necdin is a protein expressed in satellite cell-derived myogenic precursors during perinatal growth. However, its function in myogenesis is not known. We compare transgenic mice that overexpress necdin in skeletal muscle with both wild-type and necdin null mice. After muscle injury the necdin null mice show a considerable defect in muscle healing, whereas mice that overexpress necdin show a substantial increase in myofiber regeneration. We also find that in muscle, necdin increases myogenin expression, accelerates differentiation, and counteracts myoblast apoptosis. Collectively, these data clarify the function and mechanism of necdin in skeletal muscle and show the importance of necdin in muscle regeneration.

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